Risk of depression in subjects with type 2 diabetes Is modulated by a genetic variant within DRD4 gene: North Indian diabetes-depression link exploration study (NIDDLES)
journal contributionposted on 05.01.2017, 13:42 by Gurpreet Kaur, Harjot Dhillon, Ritu Sharma, Kanchan Mehta, Shallu Khullar, Sarabjit MastanaSarabjit Mastana, Monica Singh, Puneetpal Singh
The role and relevance of DRD4 gene SNPs for the risk of depression in type 2 diabetes remains to be clarified. To investigate its association, present cross sectional study was conducted on 399 type 2 diabetics who were diagnosed for depression using primary health care questionnaire-9 (PHQ-9) > 10 criteria. 191 subjects were depressed whereas, 208 subjects were found to be clinically non-depressed. Minor allele frequencies of two DRD4 SNPs rs1800955 and rs747302 were 0.45, 0.42 and 0.42, 0.34 in depressed and non depressed subjects respectively. C allele of rs747302 showed risk of depression (OR 1.41 95% CI 1.05- 1.87, P= 0.024) in comparison to G allele. It has been observed that carriers of CC genotype had approximately double the risk of depression (OR 1.96 95% CI 1.08- 3.56, P= 0.03) than GG carriers and this risk manifests in recessive mode.
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