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Role of immune cells in the removal of deleterious senescent cells

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posted on 2020-11-19, 09:59 authored by Abhijit Kale, Amit Sharma, Alexandra StolzingAlexandra Stolzing, Pierre-Yves Desprez, Judith Campisi
Cellular senescence is an essentially irreversible arrest of cell proliferation coupled to a complex senescence-associated secretory phenotype (SASP). The senescence arrest prevents the development of cancer, and the SASP can promote tissue repair. Recent data suggest that the prolonged presence of senescent cells, and especially the SASP, could be deleterious, and their beneficial effects early in life can become maladaptive such that they drive aging phenotypes and pathologies late in life. It is therefore important to develop strategies to eliminate senescent cells. There are currently under development or approved several immune cell-based therapies for cancer, which could be redesigned to target senescent cells. This review focuses on this possible use of immune cells and discusses how current cell-based therapies could be used for senescent cell removal.

Funding

SENS Research Foundation

History

School

  • Mechanical, Electrical and Manufacturing Engineering

Published in

Immunity and Ageing

Volume

17

Publisher

BioMed Central

Version

  • VoR (Version of Record)

Rights holder

© The Authors

Publisher statement

This is an Open Access Article. It is published by BioMed Central under the Creative Commons Attribution 4.0 International Licence (CC BY 4.0). Full details of this licence are available at: https://creativecommons.org/licenses/by/4.0/

Acceptance date

2020-05-18

Publication date

2020-06-03

Copyright date

2020

ISSN

1742-4933

eISSN

1742-4933

Language

  • en

Depositor

Prof Alexandra Stolzing. Deposit date: 16 November 2020

Article number

16

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