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Scalable synthesis of multicolour conjugated polymer nanoparticles via Suzuki-Miyaura polymerisation in a miniemulsion and application in bioimaging

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journal contribution
posted on 08.02.2017, 14:45 by Jonathan M. Behrendt, Jair A. Esquivel Guzman, Laura Purdie, Helen WillcockHelen Willcock, John J. Morrison, Andrew B. Foster, Rachel K. O'Reilly, Mark C. McCairn, Michael L. Turner
Suzuki cross-coupling polymerisation of aryldibromides and aryldiboronate esters in a sodium dodecyl sulfate (SDS)-stabilised miniemulsion provides a versatile and direct route to fluorescent conjugated polymer nanoparticles (CPNs). These nanoparticles have a conjugated backbone based on poly(9,9-dioctylfluorene) (PFO), however, significant structural diversity is introduced by incorporation of electron withdrawing, heterocyclic comonomers (5–50 mol.%) in order to tune the emission wavelengths from blue to far-red/near-infrared. The robust nature of the polymerisation methodology allows for rapid assessment of the relationship between polymer composition, chain morphology and optical properties of the resultant CPNs. Moreover, the CPNs (after a simple and rapid purification step) can be used directly in fluorescence-based intracellular labelling experiments (in HCT116 cells), in which they display low cytotoxicity at biologically-useful concentrations.

Funding

The authors thank the University of Manchester Intellectual Property for award of Proof of Principle funding and the Engineering and Physical Sciences Research Council (grant number EP/K039547/1). A.B.F. would like to acknowledge funding from the Knowledge Centre for Materials Chemistry (KCMC). J.A.E.G. acknowledges Conacyt for award of a PhD scholarship.

History

School

  • Aeronautical, Automotive, Chemical and Materials Engineering

Department

  • Materials

Published in

Reactive and Functional Polymers

Volume

107

Pages

69 - 77

Citation

BEHRENDT, J. M. ... et al., 2016. Scalable synthesis of multicolour conjugated polymer nanoparticles via Suzuki-Miyaura polymerisation in a miniemulsion and application in bioimaging. Reactive and Functional Polymers, 107 (October), pp. 69 - 77

Publisher

© Elsevier B.V.

Version

AM (Accepted Manuscript)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/

Publication date

2016

Notes

This article was published in the journal Reactive and Functional Polymers [© Elsevier B.V.] and the definitive version is available at: http://dx.doi.org/10.1016/j.reactfunctpolym.2016.08.006

ISSN

1381-5148

Language

en