Johnson_WC HDL EJCN submitted R1 clean.pdf (210.65 kB)
Secular changes in mid-adulthood body mass index, waist circumference, and low HDL cholesterol between 1990, 2003, and 2018 in Great Britain
journal contribution
posted on 2020-09-15, 13:10 authored by Will JohnsonWill Johnson, Tom Norris, Mark HamerObjective
To investigate the extent to which (1) secular changes in mid-adulthood WC are independent of BMI and (2) secular changes in low HDL-C are dependent on WC in each sex.
Methods
The sample comprised 19,406 adults (aged 43–47 years) from three birth cohort studies with BMI and WC measured in 1990, 2003, or 2018; 13,239 participants additionally had HDL-C measured in 2003 or 2018. Quantile regression was used to model differences between 1990–2003 and 2003–2018 in (1) BMI and WC internal Z-scores and (2) WC in cm before and after adjustment for BMI. Binary logistic regression was used to model differences between 2003 and 2018 in low HDL-C, before and after adjustment for BMI or WC.
Results
Secular increases in BMI and WC were larger between 1990 and 2003 than 2003 and 2018 and at the upper ends of the distributions. At the 85th quantile, effect sizes were larger for WC than BMI Z-scores in females but not males. Adjustment for BMI attenuated estimates of secular increases in WC in cm more in males than females. Odds ratios for low HDL-C in 2018 compared to 2003 were 1.73 (95% CI 1.32, 2.28) in males and 1.34 (1.01, 1.78) in females. Adjustment for WC did not substantially change the estimate in males but attenuated the estimate for females to 1.09 (0.81, 1.47).
Conclusions
In women much more so than in men, secular increases in mid-adulthood WC appear to have occurred independently of BMI and largely explain the observed rise in low HDL-C prevalence between 2003 and 2018.
Funding
Body size trajectories and cardio-metabolic resilience to obesity in three United Kingdom birth cohorts
Medical Research Council
Find out more...History
School
- Sport, Exercise and Health Sciences
Published in
European Journal of Clinical NutritionVolume
75Issue
3Pages
539 - 545Publisher
Springer Nature [academic journals on nature.com]Version
- AM (Accepted Manuscript)
Rights holder
© The Author(s), under exclusive licence to Springer Nature LimitedPublisher statement
This paper was accepted for publication in the journal European Journal of Clinical Nutrition and the definitive published version is available at https://doi.org/10.1038/s41430-020-00758-5.Acceptance date
2020-09-05Publication date
2020-09-16Copyright date
2020ISSN
0954-3007eISSN
1476-5640Publisher version
Language
- en
Depositor
Dr Will Johnson Deposit date: 14 September 2020Usage metrics
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