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Selective crystallisation of carbamazepine polymorphs on surfaces with differing properties

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posted on 19.06.2018, 12:20 authored by Huaiyu YangHuaiyu Yang, Cai L. Song, Ying X.S. Lim, Wenqian Chen, Jerry Y.Y. Heng
Surface-induced nucleation of carbamazepine (CBZ) in ethanol was investigated with different surface materials: glass, polytetrafluoroethylene (PTFE) and tin. The introduction of foreign surfaces with different areas and surface chemistries into the solution has an impact on the crystal morphology and polymorphic form (Form II or III). With an increase in supersaturation, a higher possibility of crystallisation of CBZ metastable Form II was observed, as expected. Increasing the number of inserts resulted in a direct increase in the surface area available for heterogeneous nucleation. The increase in surface area resulted in the greater possibility of obtaining the metastable Form II of CBZ. The stable Form III preferred to nucleate on tin rather than on glass and PTFE. The results indicate that the two different polymorphs of CBZ can be selectively crystallised out from solution with the aid of a foreign surface. The kinetic mechanism of heterogeneous nucleation of the different polymorphs induced by foreign surfaces was discussed. The potential applications will be used to control and design the crystallisation process.

Funding

EPSRC (EP/N015916/1)

History

School

  • Aeronautical, Automotive, Chemical and Materials Engineering

Department

  • Chemical Engineering

Published in

CrystEngComm

Volume

19

Issue

44

Pages

6573 - 6578

Citation

YANG, H. ... et al, 2017. Selective crystallisation of carbamazepine polymorphs on surfaces with differing properties. CrystEngComm, 19 (44), pp.6573-6578.

Publisher

© Royal Society of Chemistry

Version

VoR (Version of Record)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution 3.0 Unported (CC BY 3.0) licence. Full details of this licence are available at: http://creativecommons.org/licenses/by/3.0/

Acceptance date

13/09/2017

Publication date

2017

Notes

This is an Open Access Article. It is published by the Royal Society of Chemistry under the Creative Commons Attribution 3.0 Unported Licence (CC BY). Full details of this licence are available at: http://creativecommons.org/licenses/by/3.0/

eISSN

1466-8033

Language

en

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