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Serum sodium changes in marathon participants who use NSAIDs

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journal contribution
posted on 04.12.2018, 10:03 authored by Steven Whatmough, Stephen MearsStephen Mears, Courtney Kipps
Introduction. The primary mechanism through which the development of Exercise-Associated Hyponatremia (EAH) occurs is excessive fluid intake. However, many internal and external factors have a role in the maintenance of total body water and Non-Steroidal Anti-Inflammatory medications (NSAID) have been implicated as a risk factor for the development of EAH. This study aimed to compare serum sodium concentrations ([Na]) in participants taking an NSAID before or during a marathon (NSAID group) and those not taking an NSAID (control group). Methods. Participants in a large city marathon were recruited during race registration to participate in this study. Blood samples and body mass measurements took place on the morning of the marathon and immediately post- marathon. Blood was analysed for [Na]. Data collected via questionnaires included athlete demographics, NSAID use and estimated fluid intake. Results. We obtained a full data set for 28 participants. Of these 28 participants, 16 took an NSAID on the day of the marathon. The average serum [Na] decreased by 2.1mmol/L in the NSAID group, whilst it increased by 2.3mmol/L in the control group NSAID group (p=0.0039). Estimated fluid intake was inversely correlated with both post-marathon serum [Na] and ∆ serum [Na] (r=-0.532, p=0.004 and r=-0.405 p=0.032, respectively). Conclusion. Serum [Na] levels in participants who used an NSAID decreased over the course of the marathon whilst it increased in those who did not use an NSAID. Excessive fluid intake during a marathon was associated with a lower post-marathon serum [Na].

Funding

This project received funding from the University College London (UCL) and the British Association of Sport and Exercise Medicine (BASEM).

History

School

  • Sport, Exercise and Health Sciences

Published in

BMJ Open Sport and Exercise Medicine

Citation

WHATMOUGH, S., MEARS, S.A. and KIPPS, C., 2018. Serum sodium changes in marathon participants who use NSAIDs. BMJ Open Sport and Exercise Medicine, 4: e000364.

Publisher

BMJ Publishing Group © The Authors

Version

AM (Accepted Manuscript)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) licence. Full details of this licence are available at: http://creativecommons.org/licenses/by-nc/4.0/

Acceptance date

12/11/2018

Publication date

2018-12-05

Notes

This is an Open Access Article. It is published by BMJ publishing under the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) licence. Full details of this licence are available at: http://creativecommons.org/licenses/by-nc/4.0/

ISSN

2055-7647

Language

en