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Sex differences in age-related changes on peripheral warm and cold innocuous thermal sensitivity

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posted on 14.06.2016, 13:33 by Yoshimitsu Inoue, Nicola Gerrett, Tomoko Ichinose-Kuwahara, Yasue Umino, Saeko Kiuchi, Tatsuro Amano, Hiroyuki Ueda, George Havenith, N. Kondo
Cutaneous thermal sensitivity to a warm and cold stimulus was compared amongst 12 older (OF, 65.2±1.0year) and 29 younger (YF, 21.6±0.2years) female participants, and 17 older (OM, 66.2±1.5years) and 13 younger (YM, 21.2±0.4years) male participants to examine the effects of ageing and sex. In a neutral condition (27.5°C, 50% RH) during rest, warm and cold thermal sensitivity was measured on eight body regions (forehead, chest, back, forearm, hand, thigh, calf, and foot). Using the method of limits, a thermal stimulator was applied to the skin at an adapting temperature and either increased or decreased at a constant rate (0.3°C/s) until the participants detected the temperature with a push button. Thermal sensitivity declined with ageing to both a cold (older: 1468.6±744.7W/m(2), younger: 869.8±654.7W/m(2), p<0.001) and warm (older: 2127.0±1208.3W/m(2), younger: 1301.7±1055.2W/m(2), p<0.001) innocuous stimulus. YF and OF were more sensitive than YM and OM to both a warm and cold stimulus (p<0.05). There was no interaction between age and sex suggesting that whilst thermal sensitivity decreases with age the decrease is similar between the sexes (p>0.05). There was an interaction between temperatures, age and location and it seemed that cold thermal sensitivity was more homogenous for young and older participants however warm thermal sensitivity was more heterogeneous especially in the younger participants (p<0.05). Although the pattern was not similar between ages or sexes it was evident that the forehead was the most sensitive region to a warm and cold stimulus. Interestingly the decline in sensitivity observed with ageing occurred for all locations but was attenuated at the forehead in both males and females (p>0.05).

Funding

This study was partly supported by a Grant-in-Aid for Scientific Research (grant nos. 16500435 and 20247035).

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Published in

Physiology & behavior

Citation

INOUE, Y. ... et al., 2016. Sex differences in age-related changes on peripheral warm and cold innocuous thermal sensitivity. Physiology and Behavior, 164 (Part A), pp. 86–92.

Publisher

© Elsevier

Version

AM (Accepted Manuscript)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/

Publication date

2016

Notes

This paper was accepted for publication in the journal Physiology and Behavior and the definitive published version is available at http://dx.doi.org/10.1016/j.physbeh.2016.05.045.

ISSN

0031-9384

eISSN

1873-507X

Language

en

Exports

Loughborough Publications

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