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Silver(I) complexes of 9-anthracenecarboxylic acid and imidazoles: synthesis, structure and antimicrobial activity

journal contribution
posted on 23.07.2014, 11:18 by Malachy McCann, Robert Curran, Marcia Ben-Shoshan, Vickie McKee, Asif A. Tahir, Michael Devereux, Kevin Kavanagh, Bernadette S. Creaven, Andrew Kellett
[Ag2(9-aca)2] (1) (9-acaH = 9-anthracenecarboxylic acid) reacts with a series of imidazoles to give [Ag(imidH)2.3(CH3CN)0.7](9-aca) (3), [Ag6(imidH)4(9-aca)6(MeOH)2] (4), {[Ag(1-Me-imid)2]2[Ag4(9- aca)6]} (5), {[Ag(1-Bu-imid)2]2[Ag4(9-aca)6]} (6) and [Ag(apim)](9-aca)·H2O (7) (imidH = imidazole; 1-Me-imid = 1-methylimidazole; 1-Bu-imid = 1-butylimidazole; apim = 1-(3-aminopropyl)imidazole). The mononuclear complex 3, hexanuclear 4–6, and polymeric 7, were all characterised using X-ray crystallography. While many of the complexes possess excellent in vitro antifungal and antibacterial activities they are, unanimously, more effective against fungal cells. The insect, Galleria mellonella, can survive high doses of the Ag(I) complexes administered in vivo, and a number of the complexes offer significant protection to larvae infected with a lethal dose of pathogenic Candida albicans cells.

Funding

Financial support from the Irish Research Council for Science, Engineering and Technology (IRCSET) and the John and Pat Hume Scholarship Scheme, NUI Maynooth (R. Curran) are gratefully acknowledged.

History

School

  • Science

Department

  • Chemistry

Published in

DALTON TRANSACTIONS

Volume

41

Issue

21

Pages

6516 - 6527 (12)

Citation

McCANN, M. ... et al, 2012. Silver(I) complexes of 9-anthracenecarboxylic acid and imidazoles: synthesis, structure and antimicrobial activity. Dalton Transactions, 41(21), pp.6516-6527.

Publisher

© The Royal Society of Chemistry

Version

NA (Not Applicable or Unknown)

Publication date

2012

Notes

This item is Closed Access.

ISSN

1477-9226

Language

en

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