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Single and multi-objective shutdown optimization of a multistage continuous crystallizer

journal contribution
posted on 2024-03-28, 15:06 authored by Jiaxu LiuJiaxu Liu, Brahim BenyahiaBrahim Benyahia

This study presents the first model-based optimal shutdown procedure of a multistage continuous crystallization process which aims at the maximization of on-spec production and minimization of the shutdown time. The cooling antisolvent crystallization of Aspirin (acetylsalicylic acid) in a three-stage continuous crystallizer was used as a case study. To address the optimal shutdown problem, several single optimization scenarios were considered to assess the impact of the degrees of freedom, discretiza-tion schemes, and optimization settings such as the constraints. The proposed optimal shutdown procedures showed that significant amounts of on spec crystals can be produced both at fixed and variable shutdown times. Most importantly, the optimal shutdown procedures can match the steady state productivity, based on the shutdown to steady state productivity ratio (STSPR) which can easily reach 100%. Moreover, the residual shutdown material, considered as waste, can be dramatically reduced by >80% compared to the current standard shutdown procedures. Given the conflicting nature of the maximization of on spec production and minimization of the shutdown time, a multi-objective optimization of the shutdown operation was also addressed to identify the set of Pareto optimal solutions. Finally, a multicriteria decision aiding method, based of multi-attribute utility theory, was proposed to rank the Pareto optimal solutions to support the decision making and help identify a suitable and feasible single optimal shutdown solution.

Funding

Made Smarter Innovation - Digital Medicines Manufacturing Research Centre

Department for Business, Energy and Industrial Strategy

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History

School

  • Aeronautical, Automotive, Chemical and Materials Engineering

Department

  • Chemical Engineering

Published in

Industrial and Engineering Chemistry Research

Publisher

American Chemical Society (ACS)

Version

  • AM (Accepted Manuscript)

Publisher statement

© YYYY American Chemical Society. This document is the Accepted Manuscript version of a Published Work that appeared in final form in Industrial and Engineering Chemistry Research, after peer review and technical editing by the publisher. To access the final edited and published work see [insert hyperlinked DOI, see ACS Articles on Request https://pubs.acs.org/page/4authors/benefits/index.html#articles-request]

Acceptance date

2024-03-26

ISSN

0888-5885

eISSN

1520-5045

Language

  • en

Depositor

Prof Brahim Benyahia. Deposit date: 27 March 2024

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