CEJ-D-19-08757_Revised - Clean.pdf (2.06 MB)

Solid-liquid axial dispersion performance of a mesoscale continuous oscillatory flow crystalliser with smooth periodic constrictions using a non-invasive dual backlit imaging technique

Download (2.06 MB)
journal contribution
posted on 25.09.2019 by Iyke I Onyemelukwe, Zoltan Nagy, Chris Rielly
A dual backlit imaging technique has been developed for liquid and solid phase residence time distribution (RTD) measurements in a mesoscale (millilitre) continuous oscillatory flow crystalliser with smooth periodic constrictions (herein known as the SPC mesoscale crystalliser). The pixel-based technique enables reliable determination and direct comparison of experimentally determined hydrodynamic parameters for the liquid and solid phase without concern for errors that may be introduced by utilising different measurement techniques for each phase. Additionally, the non-invasive technique offers benefits over traditional intrusive methods as demonstrated herein. Results of solid-liquid RTD experiments reveal that for a set of oscillatory flow conditions, particles do not experience the same degree of axial dispersion and mean residence time as the continuous liquid phase. The SPC mesoscale crystalliser, however, provides solid-liquid plug flow at low net flow rates. Findings in this work emphasise the importance of characterising solid phase axial dispersion for active pharmaceutical ingredient (API) systems during continuous crystallisation development to identify minimum dispersion operating conditions essential for solid-liquid plug flow crystallisation.

Funding

EPSRC Centre for Innovative Manufacturing in Continuous Manufacturing and Crystallisation (CMAC) (EP/I033459/1)

Doctoral Training Centre in Continuous Manufacturing and Crystallisation (EP/K503289/1)

History

School

  • Aeronautical, Automotive, Chemical and Materials Engineering

Department

  • Chemical Engineering

Published in

Chemical Engineering Journal

Volume

382

Publisher

Elsevier BV

Version

AM (Accepted Manuscript)

Rights holder

© Elsevier B.V.

Publisher statement

This paper was accepted for publication in the journal Chemical Engineering Journal and the definitive published version is available at https://doi.org/10.1016/j.cej.2019.122862.

Acceptance date

16/09/2019

Publication date

2019-09-17

Copyright date

2020

ISSN

1385-8947

Language

en

Depositor

Prof Chris Rielly

Article number

122862

Exports