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Stem cells in degenerative orthopaedic pathologies: effects of aging on therapeutic potential

journal contribution
posted on 04.03.2016, 13:31 by Kivanc Atesok, Freddie H. Fu, Ichiro Sekiya, Alexandra StolzingAlexandra Stolzing, Mitsuo Ochi, Scott A. Rodeo
© 2015 European Society of Sports Traumatology, Knee Surgery, Arthroscopy (ESSKA) Purpose: The purpose of this study was to summarize the current evidence on the use of stem cells in the elderly population with degenerative orthopaedic pathologies and to highlight the pathophysiologic mechanisms behind today’s therapeutic challenges in stem cell-based regeneration of destructed tissues in the elderly patients with osteoarthritis (OA), degenerative disc disease (DDD), and tendinopathies.Methods: Clinical and basic science studies that report the use of stem cells in the elderly patients with OA, DDD, and tendinopathies were identified using a PubMed search. The studies published in English have been assessed, and the best and most recent evidence was included in the current study. Results: Evidence suggests that, although short-term results regarding the effects of stem cell therapy in degenerative orthopaedic pathologies can be promising, stem cell therapies do not appear to reverse age-related tissue degeneration. Causes of suboptimal outcomes can be attributed to the decrease in the therapeutic potential of aged stem cell populations and the regenerative capacity of these cells, which might be negatively influenced in an aged microenvironment within the degenerated tissues of elderly patients with OA, DDD, and tendinopathies. Conclusions: Clinical protocols guiding the use of stem cells in the elderly patient population are still under development, and high-level randomized controlled trials with long-term outcomes are lacking. Understanding the consequences of age-related changes in stem cell function and responsiveness of the in vivo microenvironment to stem cells is critical when designing cell-based therapies for elderly patients with degenerative orthopaedic pathologies.

History

School

  • Mechanical, Electrical and Manufacturing Engineering

Published in

Knee Surgery, Sports Traumatology, Arthroscopy

Citation

ATESOK, K. ...et al., 2017. Stem cells in degenerative orthopaedic pathologies: effects of aging on therapeutic potential. Knee Surgery, Sports Traumatology, Arthroscopy, 25 (2), pp. 626-636.

Publisher

© European Society of Sports Traumatology, Knee Surgery, Arthroscopy (ESSKA). Published by Springer

Version

VoR (Version of Record)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/

Publication date

2017

Notes

This paper is in closed access.

ISSN

0942-2056

eISSN

1433-7347

Language

en