Christian Fuchs RSC Adv 20Aug13.pdf (375.64 kB)
Download fileStudies on the double alkylation of 2,2-disubstituted-1,3-dithiacycloalkane-S-oxides: synthesis of tertiary thiol derivatives
journal contribution
posted on 2014-08-07, 12:38 authored by Christian Fuchs, Mark Edgar, Mark ElsegoodMark Elsegood, George WeaverGeorge WeaverDi-alkylation of 2,2-dimethyl-1,3-dithiacycloalkane-S-oxides has been achieved allowing the synthesis of
two tertiary thiol centres. The diastereoisomers of the mono-alkylated products have been shown to
react at different rates. The X-ray crystal structures of three substituted dithiane-S-oxides have been
determined, and the conversion of the dialkylated products into cyclic disulfide derivatives of tertiary
thiols (1,2-dithiolanes) has been achieved by treatment with acid.
Funding
The authors thank Loughborough University for financial support.
History
School
- Science
Department
- Chemistry
Published in
RSC ADVANCESVolume
3Issue
44Pages
21911 - 21918 (8)Citation
FUCHS, C. ... et al., 2013. Studies on the double alkylation of 2,2-disubstituted-1,3-dithiacycloalkane-S-oxides: synthesis of tertiary thiol derivatives. RSC Advances, 3, pp.21911-21918.Publisher
© Royal Society of ChemistryVersion
- AM (Accepted Manuscript)
Publication date
2013ISSN
2046-2069eISSN
2046-2069Publisher version
Language
- en