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Super-swelling hydrogel-forming microneedle based transdermal drug delivery: Mathematical modelling, simulation and experimental validation

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posted on 2022-05-26, 14:30 authored by Prateek Ranjan Yadav, Muhammad Iqbal Nasiri, Lalitkumar K Vora, Eneko Larrañeta, Ryan F Donnelly, Sudip K Pattanayek, Diganta DasDiganta Das

Super-swelling hydrogel-forming microneedles (HFMNs) based transdermal drug delivery (TDD) is gaining significant interest due to their non-invasiveness and ability todeliver a wide range of drugs. The HFMNs swell by imbibing interstitial skin fluid (ISF), and they facilitate drug transport from the reservoir attached at the base into the skin without polymer dissolution. To develop HFMNs for practical applications, a complete understanding of the drug transport mechanism is required, allowing for controlled TDD and geometrical optimisation. A three-phase system consisting of a reservoir, microneedle, and skin is considered. A mathematical model is developed to incorporate the drug binding within the matrix of the compartment, which was not considered earlier. Super-swelling nature of the HFMNs is incorporated through the swelling ratio obtained experimentally for a polymer. The results are validated with in vitro diffusion studies of ibuprofen sodium (IBU) across excised porcine skin, showing that around 20% of the loaded IBU in lyophilised wafer was delivered in 24 hours. It was observed that increasing IBU solubility in reservoir can achieve high drug transport across the skin. The developed model is shown to be in good agreement with the experimental data. It is concluded that the proposed model can be considered a tool with predictive design and development of super-swelling HFMNs based TDD systems.

Funding

Indian Institute of Technology Delhi, India

Des Clarke Scholarship

History

School

  • Aeronautical, Automotive, Chemical and Materials Engineering

Department

  • Chemical Engineering

Published in

International Journal of Pharmaceutics

Volume

622

Publisher

Elsevier

Version

  • AM (Accepted Manuscript)

Rights holder

© Elsevier

Publisher statement

This paper was accepted for publication in the journal International Journal of Pharmaceutics and the definitive published version is available at https://doi.org/10.1016/j.ijpharm.2022.121835

Acceptance date

2022-05-14

Publication date

2022-05-18

Copyright date

2022

ISSN

0378-5173

Language

  • en

Depositor

Dr Diganta Das. Deposit date: 14 May 2022

Article number

121835

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