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Synthesis and characterization of divinyl-fumarate Poly-ε-caprolactone for scaffolds with controlled architectures

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journal contribution
posted on 13.10.2016, 13:41 by A. Ronca, Sara Ronca, Giuseppe Forte, S. Zeppetelli, A. Gloria, R. De Santis, L. Ambrosio
A vinyl-terminated Polycaprolactone has been developed for tissue engineering applications using a one-step synthesis and functionalization method based on Ring Opening Polymerization (ROP) of ԑ-caprolactone, with Hydroxyl Ethyl Vinyl Ether (HEVE) acting both as the initiator of ROP and as photo-curable functional group. The proposed method employs a catalyst based on Al, instead of the most popular Tin(II) 2-ethylhexanoate, to reduce the cytotoxicity. Following the synthesis of the vinyl-terminated polycaprolactone, its reaction with Fumaryl Chloride (FuCl) results in a divinyl-fumarate polycaprolactone (VPCLF). The obtained polymers were thoroughly characterized using Fourier Transform Infrared Spectroscopy (FTIR) and gel permeation chromatography (GPC) techniques. The polymer has been successfully employed, in combination with N-vinyl Pyrrolidone (NVP), to fabricate films and computer-designed porous scaffolds by micro-stereolithography (μ-SL) with Gyroid and Diamond architectures. Characterization of the networks indicated the influence of NVP content on the network properties. Human Mesenchymal Stem Cells (hMSCs) adhered and spread onto VPCLF/NVP networks showing good biological properties and no cytotoxic effect.

History

School

  • Aeronautical, Automotive, Chemical and Materials Engineering

Department

  • Materials

Published in

Journal of Tissue Engineering and Regenerative Medicine

Citation

RONCA, A. ... et al, 2016. Synthesis and characterization of divinyl-fumarate Poly-ε-caprolactone for scaffolds with controlled architectures. Journal of Tissue Engineering and Regenerative Medicine, 12 (1), pp. e523–e531.

Publisher

© Wiley

Version

AM (Accepted Manuscript)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/

Acceptance date

26/09/2016

Publication date

2016

Notes

This is the peer reviewed version of the following article: RONCA, A. ... et al, 2016. Synthesis and characterization of divinyl-fumarate Poly-ε-caprolactone for scaffolds with controlled architectures. Journal of Tissue Engineering and Regenerative Medicine, doi:10.1002/term.2322., which has been published in final form at http://dx.doi.org/10.1002/term.2322. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.

ISSN

1932-7005

Language

en