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Synthesis and self-assembly of amphiphilic chiral poly(amino acid) star polymers
journal contributionposted on 2016-10-17, 11:48 authored by Jared Skey, Helen WillcockHelen Willcock, Mieke Lammens, Filip Du Prez, Rachel K. O'Reilly
Reversible addition-fragmentation chain transfer (RAFT) polymerization techniques were utilized to polymerize N-acryloyl-l-phenylalanine methyl ester (l-Phe-OMe) and tetrahydropyranyl acrylate to afford amphiphilic star polymers (with 4 and 6 arms). These copolymer stars have a chiral hydrophobic core domain and can undergo further solution self-assembly to form well-defined nanostructures, which have been characterized using DLS, TEM, and cryo-TEM analysis. The characterization and properties of these novel chiral assemblies and their potential in racemic resolution are reported.
J.S., H.W., and R.O.R. acknowledge the Royal Society, ESPRC, The Leverhulme Trust, and the University of Warwick for funding. Some of the equipment used in this research was ... part-funded by the European Regional Development Fund (ERDF). M.L. thanks the Institute for the Promotion of Innovation through Science and Technology in Flanders (IWT-Vlaanderen) for a PhD scholarship. The European Science Foundation (ESF) Scientific Programme (STIPOMAT) and the Belgian Program on Inter-University Attraction Poles initiated by the Belgian State, Prime Minister’s office (ProgramP6/27), are acknowledged for financial support.
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