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Synthesis, characterization and biological evaluation of schiff base (N-4-(thiophene-2-yl-methyleneamino)-2,6-dimethylpyrimidine-4-yl)benzenesulfonamide and its complexes with Cu(II), Ni(II), Co(II), Fe(II), Mn(II), Zn(II) ions

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posted on 29.03.2021, 12:35 authored by A Mumtaz, T Mahmud, Mark ElsegoodMark Elsegood, George WeaverGeorge Weaver, G Bratu, L Mitu
© 2020 SYSCOM 18 S.R.L.. All rights reserved. Two step synthesis of Schiff base ligand and its transition metal complexes was done by condensation reaction. In first step, the drug and aldehyde in equimolar ratio were refluxed for one hour at pH 8-9 in order to get Schiff base ligand. In second step, ligand and metal salts were refluxed for 2 hour. The ligand and Cu(II), Ni(II), Co(II), Fe(II), Mn(II), Zn(II) complexes were characterized by using different instruments like FT-IR, 1H-NMR, 13C-NMR, Mass, Atomic absorption spectrometer, Elemental analyzer, UV-visible spectrophotometer, Evans balance, Conductivitymeter and Thermogravimeter. In vitro antibacterial, antifungal and anti-inflammatory activities were also studied. The synthesized ligand and transition metal complexes were tested against Escherichia coli, Enterobacter aerogenes, Staphylococcus aureus, Bacillus pumilus, Klebsiella oxytoca, Clostridium butyrium, Mucor and Aspergillus niger. These studies demonstrated the enhanced activity of metal complexes against reported bacterial and fungal strains when compared with free Schiff base ligand. The Cu(II) complex recognized as anti-inflammatory agent while the parent drug showed no activity.

History

School

  • Science

Department

  • Chemistry

Published in

Revista de Chimie

Volume

71

Issue

1

Pages

206 - 212

Publisher

Central de Documentare Al Industriei Chimice Ri

Version

VoR (Version of Record)

Publisher statement

This is an Open Access Article. It is published by Central de Documentare Al Industriei Chimice Ri under the Creative Commons Attribution 4.0 Unported Licence (CC BY). Full details of this licence are available at: http://creativecommons.org/licenses/by/4.0/

Publication date

2020-02-07

Copyright date

2020

ISSN

0034-7752

eISSN

2668-8220

Language

en

Depositor

Dr George Weaver. Deposit date: 24 March 2021