J. Biol. Chem.-2018-Anderson-jbc.TM117.000368.pdf (912.44 kB)
Synthetic biology strategies for improving microbial synthesis of "green" biopolymers
journal contribution
posted on 2018-07-03, 10:48 authored by Lisa A. Anderson, Ahsan IslamAhsan Islam, Kristala L. PratherPolysaccharide-based biopolymers have many material properties relevant to industrial and medical uses, including as drug delivery agents, wound-healing adhesives, and food additives and stabilizers. Traditionally, polysaccharides are obtained from natural sources. Microbial synthesis offers an attractive alternative for sustainable production of tailored biopolymers. Here, we review synthetic biology strategies for select “green” biopolymers: cellulose, alginate, chitin, chitosan, and hyaluronan. Microbial production pathways, opportunities for pathway yield improvements, and advances in microbial engineering of biopolymers in various hosts are discussed. Taken together, microbial engineering has expanded the repertoire of green biological chemistry by increasing the diversity of biobased materials.
Funding
This work was supported by the National Institute of General Medical Sciences (NIGMS, Grant P50 GM098792) and the National Science Foundation (NSF, Grant MCB-1517913).
History
School
- Aeronautical, Automotive, Chemical and Materials Engineering
Department
- Chemical Engineering
Published in
JOURNAL OF BIOLOGICAL CHEMISTRYVolume
293Issue
14Pages
5053 - 5061Citation
ANDERSON, L.A., ISLAM, M.A. and PRATHER, K.L., 2018. Synthetic biology strategies for improving microbial synthesis of "green" biopolymers. Journal of Biological Chemistry, 293 (14), pp.5053-5061.Publisher
© The American Society for Biochemistry and Molecular Biology, Inc.Version
- AM (Accepted Manuscript)
Publisher statement
This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/Publication date
2018-01-16Notes
This research was originally published in the Journal of Biological Chemistry. Lisa A. Anderson, M. Ahsanul Islam, and Kristala L. J. Prather. Synthetic biology strategies for improving microbial synthesis of "green" biopolymers. J. Biol. Chem. 2018; 293:pp5053-pp5061. © the American Society for Biochemistry and Molecular Biology.ISSN
0021-9258eISSN
1083-351XPublisher version
Language
- en