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Terminal sterilization: Conventional methods versus emerging cold atmospheric pressure plasma technology for non‐viable biological tissues

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journal contribution
posted on 10.01.2017, 13:25 by Nagi M. Marsit, Laura E. Sidney, Matthew J. Branch, Sammy Wilson, Andrew Hopkinson
Tissue products are susceptible to microbial contamination from different sources, which may cause disease transmission upon transplantation. Terminal sterilization using gamma radiation, electron-beam, and ethylene oxide protocols are well established and accepted, however, such methods have known disadvantages associated with compromised tissue integrity, functionality, safety, complex logistics, availability, and cost. Non-thermal (cold) atmospheric pressure plasma (CAP) is an emerging technology that has several biomedical applications including sterilization of tissues, and the potential to surpass current terminal sterilization techniques. This review discusses the limitations of conventional terminal sterilization technologies for biological materials, and highlights the benefits of utilizing CAP.

Funding

Funding from The Authority for Research, Science, and Technology of the Ministry of Higher Education and Scientific Research-Libya (Scholarship 404/2013) is gratefully acknowledged.

History

School

  • Mechanical, Electrical and Manufacturing Engineering

Published in

Plasma Processes and Polymers

Citation

MARSIT, N.M. ...et al., 2017. Terminal sterilization: Conventional methods versus emerging cold atmospheric pressure plasma technology for non‐viable biological tissues. Plasma Processes and Polymers, 14 (7), e1600134.

Publisher

© Wiley-VCH Verlag

Version

AM (Accepted Manuscript)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/

Acceptance date

13/11/2016

Publication date

2017

Notes

This is the peer reviewed version of the following article: MARSIT, N.M. ...et al., 2017. Terminal sterilization: Conventional methods versus emerging cold atmospheric pressure plasma technology for non‐viable biological tissues. Plasma Processes and Polymers, 14 (7), e1600134, which has been published in final form at http://dx.doi.org/10.1002/ppap.201600134. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.

ISSN

1612-8869

Language

en

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