Davis et al., 2021 - LMP1 recruits and transforms fibroblasts via an ERK-dependent mechanism.pdf (15.55 MB)
Download fileThe EBV-encoded Oncoprotein, LMP1, recruits and transforms fibroblasts via an ERK-MAPK-dependent mechanism
journal contribution
posted on 2021-08-05, 12:52 authored by Alexandra M Davis, Abigail Rapley, Christopher W Dawson, Lawrence S Young, Mhairi MorrisMhairi MorrisLatent membrane protein 1 (LMP1), the major oncoprotein encoded by Epstein–Barr virus (EBV), is expressed at widely variable levels in undifferentiated nasopharyngeal carcinoma (NPC) biopsies, fueling intense debate in the field as to the importance of this oncogenic protein in disease pathogenesis. LMP1-positive NPCs are reportedly more aggressive, and in a similar vein, the presence of cancer-associated fibroblasts (CAFs) surrounding “nests” of tumour cells in NPC serve as indicators of poor prognosis. However, there is currently no evidence linking LMP1 expression and the presence of CAFs in NPC. In this study, we demonstrate the ability of LMP1 to recruit fibroblasts in vitro in an ERK-MAPK-dependent mechanism, along with enhanced viability, invasiveness and transformation to a myofibroblast-like phenotype. Taken together, these findings support a putative role for LMP1 in recruiting CAFs to the tumour microenvironment in NPC, ultimately contributing to metastatic disease.
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School
- Sport, Exercise and Health Sciences
Published in
PathogensVolume
10Issue
8Publisher
MDPI AGVersion
- VoR (Version of Record)
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© The authorsPublisher statement
This is an Open Access Article. It is published by MDPI under the Creative Commons Attribution 4.0 Unported Licence (CC BY). Full details of this licence are available at: http://creativecommons.org/licenses/by/4.0/Acceptance date
2021-07-28Publication date
2021-08-03Copyright date
2021eISSN
2076-0817Publisher version
Language
- en