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The InterLACE study: Design, data harmonization and characteristics across 20 studies on women’s health

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posted on 2016-08-18, 14:36 authored by Gita D. Mishra, Hsin-Fang Chung, Nirmala Pandeya, Annette J. Dobson, Lee Jones, Nancy E. Avis, Sybil L. Crawford, Ellen B. Gold, Daniel R. Browne, Lynette L. Sievert, Eric Brunner, Janet E. Cade, Victoria J. Burley, Darren C. Greenwood, Graham G. Giles, Fiona Bruinsma, Alissa Goodman, Kunihiko Hayashi, Jung Su Lee, Hideki Mizunuma, Diana Kuhn, Rachel Cooper, Rebecca Hardy, Carla Makhlou, Carla Makhlouf Obermeyero, Kathryn A. Leep, Mette Kildevæld Simonsen, Toyoko Yoshizawa, Nancy F. Woods, Ellen S. Mitchell, Mark Hamer, Panayotes Demakakos, Sven Sandin, Hans-Olov Adami, Elisabete Weiderpass, Debra Anderson
Objectives The International Collaboration for a Life Course Approach to Reproductive Health and Chronic Disease Events (InterLACE) project is a global research collaboration that aims to advance understanding of women’s reproductive health in relation to chronic disease risk by pooling individual participant data from several cohort and cross-sectional studies. The aim of this paper is to describe the characteristics of contributing studies and to present the distribution of demographic and reproductive factors and chronic disease outcomes in InterLACE. Study design InterLACE is an individual-level pooled study of 20 observational studies (12 of which are longitudinal) from ten countries. Variables were harmonized across studies to create a new and systematic synthesis of life-course data. Main outcome measures Harmonized data were derived in three domains: 1) socio-demographic and lifestyle factors, 2) female reproductive characteristics, and 3) chronic disease outcomes (cardiovascular disease (CVD) and diabetes). Results InterLACE pooled data from 229,054 mid-aged women. Overall, 76% of the women were Caucasian and 22% Japanese; other ethnicities (of 300 or more participants) included Hispanic/Latin American (0.2%), Chinese (0.2%), Middle Eastern (0.3%), African/black (0.5%), and Other (1.0%). The median age at baseline was 47 years (Inter-quartile range (IQR): 41-53), and that at the last follow-up was 56 years (IQR: 48-64). Regarding reproductive characteristics, half of the women (49.8%) had their first menstruation (menarche) at 12-13 years of age. The distribution of menopausal status and the prevalence of chronic disease varied considerably among studies. At baseline, most women (57%) were pre- or peri-menopausal, 20% reported a natural menopause (range 0.8-55.6%) and the remainder had had surgery or were taking hormones. By the end of follow-up, the prevalence rates of CVD and diabetes were 7.2% (range 0.9-24.6%) and 5.1% (range 1.3-13.2%), respectively. Conclusions The scale and heterogeneity of InterLACE data provide an opportunity to strengthen evidence concerning the relationships between reproductive health through life and subsequent risks of chronic disease, including cross-cultural comparisons.


InterLACE is funded by the Australian National Health and Medical Research Council (APP1027196, APP1000986).



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Mishra, G.D. ...et al., 2016. The InterLACE study: Design, data harmonization and characteristics across 20 studies on women’s health. Maturitas, 92, pp. 176–185.


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This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/

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This paper was accepted for publication in the journal Maturitas and the definitive published version is available at http://dx.doi.org/10.1016/j.maturitas.2016.07.021




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