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The acute effect of dopamine infusion on lipid and cytokine concentrations in persons with a cervical spinal cord injury – a pilot study

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journal contribution
posted on 05.01.2021, 14:15 by Sven Hoekstra, Yoshi-ichiro Kamijo, Takayoshi Matsushita, Christof LeichtChristof Leicht, Kazunari Nishiyama, Vicky Goosey-TolfreyVicky Goosey-Tolfrey, Yasunori Nagono, Yasunori Umemoto, Masumi Nakahama, Yohei Furotani, Fumihiro Tajima

Study design

Acute experimental study.


Objectives

To investigate the acute response of markers of lipid metabolism and interleukin (IL)-6 to dopamine infusion in people with a cervical spinal cord injury (CSCI).


Setting

Laboratory of Wakayama Medical University, Japan.


Methods

Ten participants, four with CSCI and six AB individuals, underwent 50 min of dopamine infusion. Blood samples were collected prior to, immediately after and 1 h following cessation of dopamine infusion for the determination of circulating catecholamine, lipid, ketone body and IL-6 concentrations.


Results

The adrenaline concentration following dopamine infusion was increased by 59 ± 7% in CSCI (p = 0.038, Cohen’s d effect size (ES): 1.47), while this was not changed in AB (p = 0.223). Triglycerides and acetoacetic acid concentration were increased in both groups, immediately after and 1 h post-infusion (triglycerides p ≤ 0.042, ES CSCI: 1.00, ES AB: 1.12; acetoacetic acid p ≤ 0.030; ES CSCI: 1.72, ES AB: 1.31). 3-Hydroxybutyric acid concentration was increased in CSCI only (48 ± 15%, p = 0.039, ES: 1.44; AB p = 0.115). Dopamine infusion did not affect plasma IL-6 concentration in either group (p ≥ 0.368).


Conclusions

Dopamine infusion induced a sustained increase in triglyceride and ketone body concentrations in persons with CSCI. In contrast, cytokine concentrations were not affected by dopamine infusion. These findings suggest that circulating catecholamines can stimulate metabolism in people with CSCI despite the presence of autonomic dysfunction.

History

School

  • Sport, Exercise and Health Sciences

Published in

Spinal Cord

Volume

59

Issue

3

Pages

274 - 281

Publisher

Springer Nature [academic journals on nature.com]

Version

AM (Accepted Manuscript)

Rights holder

© The Author(s), under exclusive licence to International Spinal Cord Society

Publisher statement

This paper was accepted for publication in the journal Spinal Cord and the definitive published version is available at https://doi.org/10.1038/s41393-021-00613-9.

Acceptance date

21/12/2020

Publication date

2021-02-09

Copyright date

2021

ISSN

1362-4393

eISSN

1476-5624

Language

en

Depositor

Prof Vicky Tolfrey Deposit date: 2 January 2021