The acute effect of dopamine infusion on lipid and cytokine concentrations in persons with a cervical spinal cord injury – a pilot study
Acute experimental study.
To investigate the acute response of markers of lipid metabolism and interleukin (IL)-6 to dopamine infusion in people with a cervical spinal cord injury (CSCI).
Laboratory of Wakayama Medical University, Japan.
Ten participants, four with CSCI and six AB individuals, underwent 50 min of dopamine infusion. Blood samples were collected prior to, immediately after and 1 h following cessation of dopamine infusion for the determination of circulating catecholamine, lipid, ketone body and IL-6 concentrations.
The adrenaline concentration following dopamine infusion was increased by 59 ± 7% in CSCI (p = 0.038, Cohen’s d effect size (ES): 1.47), while this was not changed in AB (p = 0.223). Triglycerides and acetoacetic acid concentration were increased in both groups, immediately after and 1 h post-infusion (triglycerides p ≤ 0.042, ES CSCI: 1.00, ES AB: 1.12; acetoacetic acid p ≤ 0.030; ES CSCI: 1.72, ES AB: 1.31). 3-Hydroxybutyric acid concentration was increased in CSCI only (48 ± 15%, p = 0.039, ES: 1.44; AB p = 0.115). Dopamine infusion did not affect plasma IL-6 concentration in either group (p ≥ 0.368).
Dopamine infusion induced a sustained increase in triglyceride and ketone body concentrations in persons with CSCI. In contrast, cytokine concentrations were not affected by dopamine infusion. These findings suggest that circulating catecholamines can stimulate metabolism in people with CSCI despite the presence of autonomic dysfunction.
- Sport, Exercise and Health Sciences
Published inSpinal Cord
Pages274 - 281
PublisherSpringer Nature [academic journals on nature.com]
- AM (Accepted Manuscript)
Rights holder© The Author(s), under exclusive licence to International Spinal Cord Society
Publisher statementThis paper was accepted for publication in the journal Spinal Cord and the definitive published version is available at https://doi.org/10.1038/s41393-021-00613-9.