The application of a plant-wide control strategy for an integrated continuous pharmaceutical pilot plant.
journal contributionposted on 22.05.2015, 12:55 by Richard Lakerveld, Brahim BenyahiaBrahim Benyahia, Patrick L. Heider, Haitao Zhang, Aaron Wolfe, Chris Testa, Sean Ogden, Devin R. Hersey, Salvatore Mascia, James M. Evans, Richard D. Braatz, Paul I. Barton
Continuous manufacturing offers potential opportunities for the improved manufacturing of pharmaceutical products. A key challenge is the development of an appropriate control strategy. The experimental application of an automated control strategy is presented for an end-to-end continuous pharmaceutical pilot plant. The process starts from an advanced intermediate compound and finishes with the tablet formation steps. The focus of the experimental results is on the design and performance of the control loops needed to produce a slurry of an active pharmaceutical ingredient and a solvent with specified material properties. The results demonstrate that automated control can successfully keep critical material attributes close to the desired set points for a sustained period of operation. This work aims to contribute to the development of future continuous pharmaceutical processes by providing a realistic case study of automated control of an integrated, continuous, pharmaceutical pilot plant.
Novartis International AG is acknowledged for funding of this research as well as supplying starting materials 1 and 2.
- Aeronautical, Automotive, Chemical and Materials Engineering
- Aeronautical and Automotive Engineering