The effect of 14 weeks of vitamin D3 supplementation on antimicrobial peptides and proteins in athletes
journal contributionposted on 2015-03-24, 09:45 authored by Cheng-Shiun He, William D. Fraser, Jason E. Tang, Kirsty Brown, Stephen Renwick, Jay Rudland-Thomas, James Teah, Ellie Tanqueray, Michael Gleeson
Heavy training is associated with increased respiratory infection risk and antimicrobial proteins are important in defence against oral and respiratory tract infections. We examined the effect of 14 weeks of vitamin D3 supplementation (5000 IU/day) on the resting plasma cathelicidin concentration and the salivary secretion rates of secretory immunoglobulin A (SIgA), cathelicidin, lactoferrin and lysozyme in athletes during a winter training period. Blood and saliva were obtained at the start of the study from 39 healthy men who were randomly allocated to vitamin D3 supplement or placebo. Blood samples were also collected at the end of the study; saliva samples were collected after 7 and 14 weeks. Plasma total 25(OH)D concentration increased by 130% in the vitamin D3 group and decreased by 43% in the placebo group (both P=0.001). The percentage change of plasma cathelicidin concentration in the vitamin D3 group was higher than in the placebo group (P=0.025). Only in the vitamin D3 group, the saliva SIgA and cathelicidin secretion rates increased over time (both P=0.03). A daily 5000 IU vitamin D3 supplement has a beneficial effect in up-regulating the expression of SIgA and cathelicidin in athletes during a winter training period which could improve resistance to respiratory infections.
- Sport, Exercise and Health Sciences
Published inJournal of Sports Sciences
CitationHE, C.-S. ... et al, 2016. The effect of 14 weeks of vitamin D3 supplementation on antimicrobial peptides and proteins in athletes. Journal of Sports Sciences, 34(1), pp.67-74.
PublisherRoutledge (© Taylor & Francis)
- AM (Accepted Manuscript)
Publisher statementThis work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/
NotesThis is an Accepted Manuscript of an article published by Taylor & Francis in Journal of Sports Sciences on 10 Apr 2015, available online: http://dx.doi.org/10.1080/02640414.2015.1033642