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The effect of exercise on hepatic lipid composition - a narrative review.pdf (727.38 kB)

The effect of acute and chronic exercise on hepatic lipid composition

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posted on 2023-01-06, 09:44 authored by Scott WillisScott Willis, Sundus Malaikah, Sion Parry, Stephen Bawden, Gael Ennequin, Jack Sargeant, Tom Yates, David Webb, Melanie Davies, David StenselDavid Stensel, Guruprasad Aithal, James KingJames King

Exercise is recommended for those with, or at risk of non-alcoholic fatty liver disease (NAFLD), owing to beneficial effects on hepatic steatosis and cardiometabolic risk. Whilst exercise training reduces total intra-hepatic lipid in people with NAFLD, accumulating evidence indicates that exercise may also modulate hepatic lipid composition. This metabolic influence is important as the profile of saturated (SFA), monounsaturated (MUFA) and polyunsaturated fatty acids (PUFA) dramatically affect the metabolic consequences of hepatic lipid accumulation; with SFA being especially lipotoxic. Relatedly, obesity and NAFLD are associated with hepatic PUFA depletion and elevated SFA. This review summarises the acute (single bout) and chronic (exercise training) effects of exercise on hepatic lipid composition in rodents (acute studies: n=3, chronic studies: n=13) and humans (acute studies: n=1, chronic studies: n=3). An increased proportion of hepatic PUFA after acute and chronic exercise is the most consistent finding of this review. Mechanistically, this may relate to an enhanced uptake of adipose-derived PUFA (reflecting habitual diet), particularly in rodents. A relative decrease in the proportion of hepatic MUFA after chronic exercise is also documented repeatedly, particularly in rodent models with elevated hepatic MUFA. This outcome is related to decreased hepatic stearoyl-CoA desaturase-1 activity in some studies. Findings regarding hepatic SFA are less consistent and limited by the absence of metabolic challenge in rodent models. These findings require confirmation in well-controlled interventions in people with NAFLD. These studies will be facilitated by recently validated magnetic resonance spectroscopy techniques, able to precisely quantify hepatic lipid composition in vivo.

Funding

NIHR Leicester and Nottingham Biomedical Research Centres

History

School

  • Sport, Exercise and Health Sciences

Published in

Scandinavian Journal of Medicine and Science in Sports

Volume

33

Issue

5

Pages

550-568

Publisher

Wiley

Version

  • AM (Accepted Manuscript)

Rights holder

© John Wiley & Sons A/S.

Publisher statement

This is the peer reviewed version of the following article: Willis, SA, Malaikah, S, Parry, S, et al. The effect of acute and chronic exercise on hepatic lipid composition. Scand J Med Sci Sports. 2023; 33: 550- 568. doi:10.1111/sms.14310, which has been published in final form at https://doi.org/10.1111/sms.14310. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.

Acceptance date

2023-01-04

Publication date

2023-01-16

Copyright date

2023

ISSN

0905-7188

eISSN

1600-0838

Language

  • en

Depositor

Dr James King. Deposit date: 5 January 2023

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