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The effect of specific bioactive collagen peptides on tendon remodeling during 15 wk of lower body resistance training

journal contribution
posted on 2025-05-07, 15:35 authored by Tom BalshawTom Balshaw, Mark Funnell, Emmet J. McDermott, Thomas M. Maden-Wilkinson, Garry J. Massey, Sean Abela, Btool Quteishat, Max Edsey, Lewis JamesLewis James, Jonathan FollandJonathan Folland

Purpose: Collagen peptide supplementation has been reported to enhance synthesis rates or growth in a range of musculoskeletal tissues and could enhance tendinous tissue adaptations to resistance training (RT). This double-blind placebo-controlled study aimed to determine if tendinous tissue adaptations, size (patellar tendon cross-sectional area (CSA) and vastus lateralis (VL) aponeurosis area), and mechanical properties (patellar tendon), after 15 wk of RT, could be augmented with collagen peptide (CP) versus placebo (PLA) supplementation. Methods: Young healthy recreationally active men were randomized to consume either 15 g of CP (n = 19) or PLA (n = 20) once every day during a standardized program of lower-body RT (3 times a week). Measurements pre- and post-RT included patellar tendon CSA and VL aponeurosis area (via magnetic resonance imaging), and patellar tendon mechanical properties during isometric knee extension ramp contractions. Results: No between-group differences were detected for any of the tendinous tissue adaptations to RT (ANOVA group–time, 0.365 ≤ P ≤ 0.877). There were within-group increases in VL aponeurosis area (CP, +10.0%; PLA, +9.4%), patellar tendon stiffness (CP, +17.3%; PLA, +20.9%) and Young’s modulus (CP, +17.8%; PLA, +20.6%) in both groups (paired t-tests (all), P ≤ 0.007). There were also within-group decreases in patellar tendon elongation (CP, −10.8%; PLA, −9.6%) and strain (CP, −10.6%; PLA, −8.9%) in both groups (paired t-tests (all), P ≤ 0.006). Although no within-group changes in patellar tendon CSA (mean or regional) occurred for CP or PLA, a modest overall time effect (n = 39) was observed for mean (+1.4%) and proximal region (+2.4%) patellar tendon CSA (ANOVA, 0.017 ≤ P ≤ 0.048). Conclusions: In conclusion, CP supplementation did not enhance RT-induced tendinous tissue remodeling (either size or mechanical properties) compared with PLA within a population of healthy young men.

History

School

  • Sport, Exercise and Health Sciences

Published in

Medicine & Science in Sports & Exercise

Volume

55

Issue

11

Pages

2083 - 2095

Publisher

Lippincott, Williams & Wilkins

Version

  • VoR (Version of Record)

Rights holder

© American College of Sports Medicine

Acceptance date

2023-06-01

Publication date

2023-11-01

Copyright date

2023

ISSN

0195-9131

eISSN

1530-0315

Language

  • en

Depositor

Dr Tom Balshaw. Deposit date: 2 April 2025

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