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The Evolution of the Age of Onset of Resistance to Infectious Disease.pdf (982.17 kB)

The evolution of the age of onset of resistance to infectious disease

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posted on 2024-01-12, 12:12 authored by Lydia Buckingham, Ben Ashby

Many organisms experience an increase in disease resistance as they age, but the time of life at which this change occurs varies. Increases in resistance are partially due to prior exposure and physiological constraints, but these cannot fully explain the observed patterns of age-related resistance. An alternative explanation is that developing resistance at an earlier age incurs costs to other life-history traits. Here, we explore how trade-offs with host reproduction or mortality affect the evolution of the onset of resistance, depending on when during the host’s life cycle the costs are paid (only when resistance is developing, only when resistant or throughout the lifetime). We find that the timing of the costs is crucial to determining evolutionary outcomes, often making the difference between resistance developing at an early or late age. Accurate modelling of biological systems therefore relies on knowing not only the shape of trade-offs but also when they take effect. We also find that the evolution of the rate of onset of resistance can result in evolutionary branching. This provides an alternative, possible evolutionary history of populations which are dimorphic in disease resistance, where the rate of onset of resistance has diversified rather than the level of resistance.

Funding

Host-parasite coevolution in complex communities

Natural Environment Research Council

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NSFDEB-NERC: The eco-evolutionary dynamics of age-specific resistance to infectious disease

Natural Environment Research Council

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Milner Scholarship PhD grant from The Evolution Education Trust

Natural Sciences and Engineering Research Council of Canada (NSERC)

BC Ministry of Health

History

School

  • Science

Department

  • Mathematics Education Centre

Published in

Bulletin of Mathematical Biology

Volume

85

Issue

5

Publisher

Springer

Version

  • VoR (Version of Record)

Rights holder

© The Author(s)

Publisher statement

This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

Acceptance date

2023-03-13

Publication date

2023-04-15

Copyright date

2023

ISSN

0092-8240

eISSN

1522-9602

Language

  • en

Depositor

Lydia Buckingham. Deposit date: 12 January 2024

Article number

42

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