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The impact of a graded maximal exercise protocol on exhaled volatile organic compounds: a pilot study

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journal contribution
posted on 10.01.2022, 14:24 by Liam HeaneyLiam Heaney, Shuo Kang, Matthew TurnerMatthew Turner, Martin LindleyMartin Lindley, Paul Thomas
Exhaled volatile organic compounds (VOCs) are of interest due to their minimally invasive sampling procedure. Previous studies have investigated the impact of exercise, with evidence suggesting that breath VOCs reflect exercise-induced metabolic activity. However, these studies have yet to investigate the impact of maximal exercise to exhaustion on breath VOCs, which was the main aim of this study. Two-litre breath samples were collected onto thermal desorption tubes using a portable breath collection unit. Samples were collected pre-exercise, and at 10 and 60 min following a maximal exercise test (VO2MAX). Breath VOCs were analysed by thermal desorption-gas chromatography-mass spectrometry using a non-targeted approach. Data showed a tendency for reduced isoprene in samples at 10 min post-exercise, with a return to baseline by 60 min. However, inter-individual variation meant differences between baseline and 10 min could not be confirmed, although the 10 and 60 min timepoints were different (p = 0.041). In addition, baseline samples showed a tendency for both acetone and isoprene to be reduced in those with higher absolute VO2MAX scores (mL(O2)/min), although with restricted statistical power. Baseline samples could not differentiate between relative VO2MAX scores (mL(O2)/kg/min). In conclusion, these data support that isoprene levels are dynamic in response to exercise.

Funding

Loughborough University Graduate School

History

School

  • Science
  • Sport, Exercise and Health Sciences

Department

  • Chemistry

Published in

Molecules

Volume

27

Issue

2

Publisher

MDPI AG

Version

VoR (Version of Record)

Rights holder

© The Authors

Publisher statement

This is an Open Access Article. It is published by MDPI under the Creative Commons Attribution 4.0 International Licence (CC BY 4.0). Full details of this licence are available at: https://creativecommons.org/licenses/by/4.0/

Acceptance date

06/01/2022

Publication date

2022-01-07

Copyright date

2022

eISSN

1420-3049

Language

en

Depositor

Dr Liam Heaney. Deposit date: 7 January 2022

Article number

370