Esh, Taylor (2021) Influence of Env Temp and Tc on COX and PGE2.pdf (2.01 MB)

The influence of environmental and core temperature on cyclooxygenase and PGE2 in healthy humans

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journal contribution
posted on 03.06.2021, 08:09 by Chris Esh, Bryna CR Chrismas, Alexis R Mauger, Anissa Cherif, John Molphy, Lee Taylor
Whether cyclooxygenase (COX)/prostaglandin E2 (PGE2) thermoregulatory pathways, observed in rodents, present in humans? Participants (n = 9) were exposed to three environments; cold (20 °C), thermoneutral (30 °C) and hot (40 °C) for 120 min. Core (Tc)/skin temperature and thermal perception were recorded every 15 min, with COX/PGE2 concentrations determined at baseline, 60 and 120 min. Linear mixed models identified differences between and within subjects/conditions. Random coefficient models determined relationships between Tc and COX/PGE2. Tc [mean (range)] increased in hot [+ 0.8 (0.4–1.2) °C; p < 0.0001; effect size (ES): 2.9], decreased in cold [− 0.5 (− 0.8 to − 0.2) °C; p < 0.0001; ES 2.6] and was unchanged in thermoneutral [+ 0.1 (− 0.2 to 0.4) °C; p = 0.3502]. A relationship between COX2/PGE2 in cold (p = 0.0012) and cold/thermoneutral [collapsed, condition and time (p = 0.0243)] was seen, with higher PGE2 associated with higher Tc. A within condition relationship between Tc/PGE2 was observed in thermoneutral (p = 0.0202) and cold/thermoneutral [collapsed, condition and time (p = 0.0079)] but not cold (p = 0.0631). The data suggests a thermogenic response of the COX/PGE2 pathway insufficient to defend Tc in cold. Further human in vivo research which manipulates COX/PGE2 bioavailability and participant acclimation/acclimatization are warranted to elucidate the influence of COX/PGE2 on Tc.

Funding

Aspire Zone Foundation (Doha, Qatar)

History

School

  • Sport, Exercise and Health Sciences

Published in

Scientific Reports

Volume

11

Issue

1

Publisher

Springer Nature

Version

VoR (Version of Record)

Rights holder

© The Authors

Publisher statement

This is an Open Access Article. It is published by Springer Nature under the Creative Commons Attribution 4.0 International Licence (CC BY 4.0). Full details of this licence are available at: https://creativecommons.org/licenses/by/4.0/

Acceptance date

21/01/2021

Publication date

2021-03-22

Copyright date

2021

ISSN

2045-2322

eISSN

2045-2322

Language

en

Depositor

Dr Lee Taylor. Deposit date: 1 June 2021

Article number

6531