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The mediating effect of different exercise programs on the immune profile of frail older women with cognitive impairment

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posted on 2020-07-16, 09:22 authored by Furtado G Eustáquio, Chupel M Uba, Minuzzi L Guerra, Rama Luis, Colado J Carlos, Eef HogervorstEef Hogervorst, Ferreira J Pedro, Teixeira A Maria
Background: Frail individuals experience an accelerated immunosenescence, and exercise has been identified as a therapy to promote a better inflammatory environment. Objective: To analyze the effects of 28-weeks of two different exercise protocols on the functional fitness and immune profiles of institutionalized pre-frail and frail women with mild cognitive impairment. Methods: Participants residing in care homes (n=60, 81±7.84 years old) were randomized into three groups: a chair elastic band muscle-strength exercise (CSE, n=21; 81±4.79), a chair multimodal exercise (CME, n=20; 80±8.19), and a control non-exercise (CGne, n=19; 80±10.01). Both CME and CSE groups performed progressive circuit-training exercise sessions. The controls did not change their usual lifestyle. The Fried protocol and the Mini-Mental State Examination questionnaire were used to identify the frail subgroups and the participants with mild cognitive impairment. Data for anti and pro-inflammatory markers and physical fitness were analyzed pre and post-interventions. Results: After the intervention, a significant effect of time and time by group for sIgA and time by group for IL- 10 levels were found (p > 0.05). Within-group analysis showed a significant moderate decrease in the TNF-α to IL-10 ratio for the CME group and an increase in the controls (p > 0.05) and a slight reduction in the IL-6 and IL- 1β concentrations. The controls showed a negative trend towards a decrease in physical fitness and a trend for increased levels in the pro-inflammatory markers IL-6 and IL-1β. Conclusions: The evidence regarding the use of systematic and moderate long-term exercise as therapy for promoting a better balance between pro- and anti-inflammatory environments and a decrease in the inflammatory index for the CME group were the most promising results from this study.

History

School

  • Sport, Exercise and Health Sciences

Published in

Current Pharmaceutical Design

Volume

26

Issue

9

Pages

906 - 915

Publisher

Bentham Science Publishers Ltd.

Version

  • AM (Accepted Manuscript)

Rights holder

© Bentham Science Publishers Ltd.

Publisher statement

This paper was accepted for publication in the journal Current Pharmaceutical Design and the definitive published version is available at https://doi.org/10.2174/1381612826666200203123258

Acceptance date

2019-11-25

Publication date

2020-04-23

Copyright date

2020

ISSN

1381-6128

eISSN

1873-4286

Language

  • en

Location

United Arab Emirates

Depositor

Prof Eef Hogervorst . Deposit date: 15 July 2020