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The mediating effect of different exercise programs on the immune profile of frail older women with cognitive impairment
journal contribution
posted on 2020-07-16, 09:22 authored by Furtado G Eustáquio, Chupel M Uba, Minuzzi L Guerra, Rama Luis, Colado J Carlos, Eef HogervorstEef Hogervorst, Ferreira J Pedro, Teixeira A MariaBackground:
Frail individuals experience an accelerated immunosenescence, and exercise has been
identified as a therapy to promote a better inflammatory environment.
Objective:
To analyze the effects of 28-weeks of two different exercise protocols on the functional fitness and
immune profiles of institutionalized pre-frail and frail women with mild cognitive impairment.
Methods:
Participants residing in care homes (n=60, 81±7.84 years old) were randomized into three groups: a
chair elastic band muscle-strength exercise (CSE, n=21; 81±4.79), a chair multimodal exercise (CME, n=20;
80±8.19), and a control non-exercise (CGne, n=19; 80±10.01). Both CME and CSE groups performed
progressive circuit-training exercise sessions. The controls did not change their usual lifestyle. The Fried protocol
and the Mini-Mental State Examination questionnaire were used to identify the frail subgroups and the
participants with mild cognitive impairment. Data for anti and pro-inflammatory markers and physical fitness
were analyzed pre and post-interventions.
Results:
After the intervention, a significant effect of time and time by group for sIgA and time by group for IL-
10 levels were found (p > 0.05). Within-group analysis showed a significant moderate decrease in the TNF-α to
IL-10 ratio for the CME group and an increase in the controls (p > 0.05) and a slight reduction in the IL-6 and IL-
1β concentrations. The controls showed a negative trend towards a decrease in physical fitness and a trend for
increased levels in the pro-inflammatory markers IL-6 and IL-1β.
Conclusions:
The evidence regarding the use of systematic and moderate long-term exercise as therapy for
promoting a better balance between pro- and anti-inflammatory environments and a decrease in the inflammatory
index for the CME group were the most promising results from this study.
History
School
- Sport, Exercise and Health Sciences
Published in
Current Pharmaceutical DesignVolume
26Issue
9Pages
906 - 915Publisher
Bentham Science Publishers Ltd.Version
- AM (Accepted Manuscript)
Rights holder
© Bentham Science Publishers Ltd.Publisher statement
This paper was accepted for publication in the journal Current Pharmaceutical Design and the definitive published version is available at https://doi.org/10.2174/1381612826666200203123258Acceptance date
2019-11-25Publication date
2020-04-23Copyright date
2020ISSN
1381-6128eISSN
1873-4286Publisher version
Language
- en
Location
United Arab EmiratesDepositor
Prof Eef Hogervorst . Deposit date: 15 July 2020Usage metrics
Categories
No categories selectedKeywords
Frail older adultsmuscle-strengthmultimodalexercisecytokinesinflammationupper respiratory tract infectorScience & TechnologyLife Sciences & BiomedicinePharmacology & PharmacyCHRONIC INFLAMMATIONMUSCLE STRENGTHVALIDATIONADULTSSOCIETYDISEASEMARKERSupper respiratory tract infector.Medicinal & Biomolecular ChemistryPharmacology and Pharmaceutical Sciences
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