Loughborough University
Browse
fnins-15-753820.pdf (1.45 MB)

The menstrual cycle modulates whole-brain turbulent dynamics

Download (1.45 MB)
journal contribution
posted on 2024-03-27, 10:44 authored by Eleonora De Filippi, Carme Uribe, Daniela S Avila-Varela, Noelia Martínez-Molina, Venera GashajVenera Gashaj, Laura Pritschet, Tyler Santander, Emily G Jacobs, Morten L Kringelbach, Yonatan Sanz Perl, Gustavo Deco, Anira Escrichs
Brain dynamics have recently been shown to be modulated by rhythmic changes in female sex hormone concentrations across an entire menstrual cycle. However, many questions remain regarding the specific differences in information processing across spacetime between the two main follicular and luteal phases in the menstrual cycle. Using a novel turbulent dynamic framework, we studied whole-brain information processing across spacetime scales (i.e., across long and short distances in the brain) in two open-source, dense-sampled resting-state datasets. A healthy naturally cycling woman in her early twenties was scanned over 30 consecutive days during a naturally occurring menstrual cycle and under a hormonal contraceptive regime. Our results indicated that the luteal phase is characterized by significantly higher information transmission across spatial scales than the follicular phase. Furthermore, we found significant differences in turbulence levels between the two phases in brain regions belonging to the default mode, salience/ventral attention, somatomotor, control, and dorsal attention networks. Finally, we found that changes in estradiol and progesterone concentrations modulate whole-brain turbulent dynamics in long distances. In contrast, we reported no significant differences in information processing measures between the active and placebo phases in the hormonal contraceptive study. Overall, the results demonstrate that the turbulence framework is able to capture differences in whole-brain turbulent dynamics related to ovarian hormones and menstrual cycle stages.

Funding

Human Brain Project Specific Grant Agreement 3

European Commission

Find out more...

History

School

  • Science

Department

  • Mathematics Education Centre

Published in

Frontiers in Neuroscience

Volume

15

Publisher

Frontiers Media

Version

  • VoR (Version of Record)

Rights holder

© De Filippi, Uribe, Avila-Varela, Martínez-Molina, Gashaj, Pritschet, Santander, Jacobs, Kringelbach, Sanz Perl, Deco and Escrichs

Publisher statement

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

Acceptance date

2021-11-11

Publication date

2021-12-09

Copyright date

2021

ISSN

1662-4548

eISSN

1662-453X

Language

  • en

Depositor

Dr Venera Gashaj. Deposit date: 25 March 2024

Article number

753820

Usage metrics

    Loughborough Publications

    Licence

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC