The role of TLR4, TNF-α and IL-1β in type 2 diabetes mellitus development within a North Indian Population.

Doody, Nat; Dowejko, Monika; Akam, Liz; Cox, Nick; Bhatti, Jasvinder Singh; Singh, Puneetpal; Mastana, Sarabjit

The role of TLR4, TNF-α and IL-1β in type 2 diabetes mellitus development within a North Indian Population.

journal contribution

posted on 2017-06-26, 10:54 authored by Nat Doody, Monika Dowejko, Liz AkamLiz Akam, Nick CoxNick Cox, Jasvinder Singh Bhatti, Puneetpal Singh, Sarabjit MastanaSarabjit Mastana

This study investigated the role of IL-1β-511 (rs16944), TLR4-896 (rs4986790) and TNF-α-308 (rs1800629) polymorphisms in type 2 diabetes mellitus (T2DM) among an endogamous Northern Indian population. 414 participants (204 T2DM patients and 210 non-diabetic controls) were genotyped for IL-1β-511, TLR4-896 and TNF-α-308 loci. The C allele of IL-1β-511 was shown to increase T2DM susceptibility by 75% (OR: 1.75 [CI 1.32-2.33]). Having two parents affected by T2DM increased susceptibility by 5.7 times (OR: 5.693 [CI 1.431-22.648]). In this study, we have demonstrated a conclusive association with IL-1β-511 locus and IL1B-511-TLR4-896 diplotype (CC-AA) and T2DM, which warrants further comprehensive analyses in larger cohorts.

History

School

Sport, Exercise and Health Sciences

Published in

Annals of Human Genetics

Volume

81

Pages

141 - 146 (6)

Citation

DOODY, N.E. ...et al., 2017. The role of TLR4, TNF-α and IL-1β in type 2 diabetes mellitus development within a North Indian Population. Annals of Human Genetics, 81, pp. 141-146.

Publisher

Version

VoR (Version of Record)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/

Acceptance date

2017-04-25

Publication date

2017-06-16

Notes

"This is the peer reviewed version of the following article: DOODY, N.E. ...et al., 2017. The role of TLR4, TNF-α and IL-1β in type 2 diabetes mellitus development within a North Indian Population. Annals of Human Genetics, 81, pp. 141-146, which has been published in final form at http://dx.doi.org/10.1111/ahg.12197. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.