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The selective mono and difunctionalization of carbocyclic cleft molecules with pyridyl groups and X-ray crystallographic analysis

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posted on 10.01.2014 by Priti Jilka, Claire Millington, Mark Elsegood, Josef W.A. Frese, Simon J. Teat, Marc Kimber
The diesterification and selective mono and dialkylation of carbocyclic analogues of Tröger’s base with pyridyl groups has been achieved in high yield and good selectivity giving access to a novel range of cleft molecules capable of binding events. Reaction conditions for the selective functionalization of this carbocyclic cleft molecule are discussed as well as the solid state structures of these newly synthesized ligands.

History

School

  • Science

Department

  • Chemistry

Citation

JILKA, P. ... et al, 2010. The selective mono and difunctionalization of carbocyclic cleft molecules with pyridyl groups and X-ray crystallographic analysis. Tetrahedron, 66 (48), pp. 9327 - 9331

Publisher

© Elsevier Ltd

Version

AM (Accepted Manuscript)

Publication date

2010

Notes

This article was published in the journal Tetrahedron [© Elsevier Ltd]. The definitive version is available at: http://dx.doi.org/10.1016/j.tet.2010.10.027

ISSN

0040-4020

Language

en

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