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The skeletal muscle response to energy deficiency: a life history perspective

journal contribution
posted on 02.03.2022, 09:30 by Gersiel Oliveira-Junior, Rafaela S Pinto, Meghan K Shirley, Daniel LongmanDaniel Longman, Karsten Koehler, Bryan Saunders, Hamilton Roschel, Eimear Dolan
Energy is a finite resource that is competitively distributed among the body’s systems and biological processes. During times of scarcity, energetic “trade-offs” may arise if less energy is available than is required to optimally sustain all systems. More immediately essential functions are predicted to be prioritized, even if this necessitates the diversion of energy away from – and potential downregulation of – others. These concepts are encompassed within life history theory, an evolutionary framework with considerable potential to enhance understanding of the evolved biological response to periods of energy deficiency. Skeletal muscle is a particularly interesting tissue to investigate from this perspective, given that it is one of the largest and most energetically costly tissues within the body. It is also highly plastic, responsive to a broad range of stimuli, and contributes to many essential bodily functions, e.g., mechanical, regulatory and storage. These functions may be traded off against each other during periods of energy deficiency, with the nature of the trade-off’s dependent on the characteristics of the individual and the circumstances within which the deficit occurs. In this review, we consider the skeletal muscle response to periods of energy deficiency from a life history perspective, along with how this response may be influenced by factors including sex, age, body composition, training and nutritional status.

Funding

Fundação de Ampara a Pesquisa do Estado do São Paulo (FAPESP: 2019/05616-6, 2019/26899-6, 2016/50438-0 and 2020/07540-4)

Faculdade de Medicina da Universidade de São Paulo (2020.1.362.5.2)

History

School

  • Sport, Exercise and Health Sciences

Published in

Adaptive Human Behavior and Physiology

Volume

8

Issue

1

Pages

114 - 129

Publisher

Springer

Version

AM (Accepted Manuscript)

Rights holder

© The Author(s), under exclusive licence to Springer Nature Switzerland AG

Publisher statement

This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/10.1007/s40750-021-00182-4.

Acceptance date

17/12/2021

Publication date

2022-01-24

Copyright date

2022

eISSN

2198-7335

Language

en

Depositor

Dr Danny Longman. Deposit date: 1 March 2022