Andersen2021_Article_TheUseOfPlatelet-RichPlasmaPRP.pdf (1.02 MB)

The use of platelet-rich plasma (PRP) for the management of non-union fractures

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journal contribution
posted on 06.01.2021, 17:04 by Christian Andersen, Nicholas Wragg, Maryam Shariatzadeh, Sammy Wilson
Purpose of Review The treatment of non-union fractures represents a significant challenge for orthopaedic surgeons. In recent years, biologic agents have been investigated and utilised to support and improve bone healing. Among these agents, platelet-rich plasma (PRP) is an emerging strategy that is gaining popularity. The aim of this review is to evaluate the current literature regarding the application and clinical effectiveness of PRP injections, specifically for the treatment of non-union fractures. Recent Findings The majority of published studies reported that PRP accelerated fracture healing; however, this evidence was predominantly level IV. The lack of randomised, clinical trials (level I–II evidence) is currently hampering the successful clinical translation of PRP as a therapy for non-union fractures. This is despite the positive reports regarding its potential to heal non-union fractures, when used in isolation or in combination with other forms of treatment. Summary Future recommendations to facilitate clinical translation and acceptance of PRP as a therapy include the need to investigate the effects of administering higher volumes of PRP (i.e. 5–20 mL) along with the requirement for more prolonged (> 11 months) randomised clinical trials.

History

School

  • Mechanical, Electrical and Manufacturing Engineering

Published in

Current Osteoporosis Reports

Volume

19

Pages

1-14

Publisher

Springer Science and Business Media LLC

Version

VoR (Version of Record)

Rights holder

© The Authors

Publisher statement

This is an Open Access Article. It is published by Springer under the Creative Commons Attribution 4.0 International Licence (CC BY 4.0). Full details of this licence are available at: https://creativecommons.org/licenses/by/4.0/

Acceptance date

04/12/2020

Publication date

2021-01-04

Copyright date

2021

ISSN

1544-1873

eISSN

1544-2241

Language

en

Depositor

Dr Sammy Wilson. Deposit date: 4 January 2021

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