Tissue engineered organoids for neural network modelling
journal contributionposted on 2018-10-01, 09:12 authored by Matthew Kose-Dunn, Rosemary Fricker, Paul RoachPaul Roach
The increased prevalence of neurological diseases across the world has stimulated a great deal of research into the physiological and pathological brain, both at clinical and pre-clinical level. This has led to the development of many sophisticated tissue engineered neural models, presenting greater cellular complexity to better mimic the central nervous system niche environment. These have been developed with the ambition to improve pre-clinical assessment of pharma and cellular therapies, as well as better understand this tissue type and its function/dysfunction. This review covers the necessary considerations in in vitro model design, along with recent advances in 2Dculture systems, to 3D organoids and bio-artificial organs.
EPSRC-MRC Centre for Doctoral Training in Regenerative Medicine (EP/L015072/1).