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Tissue engineered organoids for neural network modelling

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journal contribution
posted on 01.10.2018, 09:12 by Matthew Kose-Dunn, Rosemary Fricker, Paul RoachPaul Roach
The increased prevalence of neurological diseases across the world has stimulated a great deal of research into the physiological and pathological brain, both at clinical and pre-clinical level. This has led to the development of many sophisticated tissue engineered neural models, presenting greater cellular complexity to better mimic the central nervous system niche environment. These have been developed with the ambition to improve pre-clinical assessment of pharma and cellular therapies, as well as better understand this tissue type and its function/dysfunction. This review covers the necessary considerations in in vitro model design, along with recent advances in 2Dculture systems, to 3D organoids and bio-artificial organs.

Funding

EPSRC-MRC Centre for Doctoral Training in Regenerative Medicine (EP/L015072/1).

History

School

  • Science

Department

  • Chemistry

Published in

Advances in Tissue Engineering & Regenerative Medicine: Open Access

Volume

3

Issue

3

Citation

KOSE-DUNN, M., FRICKER, R. and ROACH, P., 2017. Tissue engineered organoids for neural network modelling. Advances in Tissue Engineering & Regenerative Medicine: Open Access, 3 (3), pp.391-401.

Publisher

MedCrave

Version

VoR (Version of Record)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) licence. Full details of this licence are available at: http://creativecommons.org/licenses/by-nc/4.0/

Publication date

2017-12-15

Notes

This is an Open Access Article. It is published by MedCrave under the Creative Commons Attribution-NonCommercial 4.0 International Licence (CC BY-NC). Full details of this licence are available at: http://creativecommons.org/licenses/by-nc/4.0/

eISSN

2572-8490

Language

en