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Tissue engineering of the retina: from organoids to microfluidic chips

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posted on 2021-12-16, 13:24 authored by Luis Marcos, Sammy WilsonSammy Wilson, Paul RoachPaul Roach
Despite advancements in tissue engineering, challenges remain for fabricating functional tissues that incorporate essential features including vasculature and complex cellular organisation. Monitoring of engineered tissues also raises difficulties, particularly when cell population maturity is inherent to function. Microfluidic, or lab-on-a-chip, platforms address the complexity issues of conventional 3D models regarding cell numbers and functional connectivity. Regulation of biochemical/biomechanical conditions can create dynamic structures, providing microenvironments that permit tissue formation while quantifying biological processes at a single cell level. Retinal organoids provide relevant cell numbers to mimic in vivo spatiotemporal development, where conventional culture approaches fail. Modern bio-fabrication techniques allow for retinal organoids to be combined with microfluidic devices to create anato-physiologically accurate structures or ‘ retina-on-a-chip’ devices that could revolution ocular sciences. Here we present a focussed review of retinal tissue engineering, examining the challenges and how some of these have been overcome using organoids, microfluidics, and bioprinting technologies.

Funding

EPSRC and MRC Centre for Doctoral Training in Regenerative Medicine

Engineering and Physical Sciences Research Council

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History

School

  • Mechanical, Electrical and Manufacturing Engineering
  • Science

Department

  • Chemistry

Published in

Journal of Tissue Engineering

Volume

12

Pages

1-27

Publisher

SAGE Publications

Version

  • VoR (Version of Record)

Rights holder

© The authors

Publisher statement

This is an Open Access Article. It is published by Sage under the Creative Commons Attribution 4.0 Unported Licence (CC BY). Full details of this licence are available at: http://creativecommons.org/licenses/by/4.0/

Acceptance date

2021-10-28

Publication date

2021-12-10

Copyright date

2021

ISSN

2041-7314

eISSN

2041-7314

Language

  • en

Depositor

Dr Sammy Wilson. Deposit date: 16 December 2021

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