Synlett alternaramide revised LUPIN.pdf (538.44 kB)

Total synthesis of the marine-derived cyclic depsipeptide alternaramide

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journal contribution
posted on 09.01.2014, 15:14 by Alexandra E. Horton, Oliver S. May, Mark Elsegood, Marc Kimber
The first synthesis of the marine fungus derived natural product alternaramide is described using solution phase coupling protocols and via a macrolactonization and macrolactamization route. The structure of alternaramide was confirmed and was supported by single crystal X-ray analysis which exhibited three similar molecules in the asymmetric unit, each with transannular hydrogen bonds.

History

School

  • Science

Department

  • Chemistry

Citation

HORTON, A.E. ... et al, 2011. Total synthesis of the marine-derived cyclic depsipeptide alternaramide. Synlett, 22 (6), pp. 797 - 800

Publisher

© Georg Thieme Verlag

Version

AM (Accepted Manuscript)

Publication date

2011

Notes

This article was published in the journal, Synlett [© Georg Thieme Verlag]. The definitive version is available at: http://dx.doi.org/10.1055/s-0030-1259915

ISSN

0936-5214

Language

en