Total synthesis of the marine-derived cyclic depsipeptide alternaramide

Horton, Alexandra E.; May, Oliver S.; Elsegood, Mark; Kimber, Marc

Total synthesis of the marine-derived cyclic depsipeptide alternaramide

journal contribution

posted on 2014-01-09, 15:14 authored by Alexandra E. Horton, Oliver S. May, Mark ElsegoodMark Elsegood, Marc KimberMarc Kimber

The first synthesis of the marine fungus derived natural product alternaramide is described using solution phase coupling protocols and via a macrolactonization and macrolactamization route. The structure of alternaramide was confirmed and was supported by single crystal X-ray analysis which exhibited three similar molecules in the asymmetric unit, each with transannular hydrogen bonds.

History

School

Science

Department

Chemistry

Citation

HORTON, A.E. ... et al, 2011. Total synthesis of the marine-derived cyclic depsipeptide alternaramide. Synlett, 22 (6), pp. 797 - 800

Publisher

Version

AM (Accepted Manuscript)

Publication date

2011

Notes

This article was published in the journal, Synlett [© Georg Thieme Verlag]. The definitive version is available at: http://dx.doi.org/10.1055/s-0030-1259915