Synlett alternaramide revised LUPIN.pdf (538.44 kB)
Download fileTotal synthesis of the marine-derived cyclic depsipeptide alternaramide
journal contribution
posted on 09.01.2014, 15:14 by Alexandra E. Horton, Oliver S. May, Mark ElsegoodMark Elsegood, Marc KimberMarc KimberThe first synthesis of the marine fungus derived natural product alternaramide is described using solution phase coupling protocols and via a macrolactonization and macrolactamization route. The structure of alternaramide was confirmed and was supported by single crystal X-ray analysis which exhibited three similar molecules in the asymmetric unit, each with transannular hydrogen bonds.
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