Loughborough University
Browse
CBM 2024 Trabecula-level mechanoadaptation - Numerical analysis of morphological changes.pdf (9.68 MB)

Trabecula-level mechanoadaptation: numerical analysis of morphological changes

Download (9.68 MB)
journal contribution
posted on 2024-01-05, 15:06 authored by Ekaterina SmotrovaEkaterina Smotrova, Simin LiSimin Li, Vadim SilberschmidtVadim Silberschmidt

Background: Bone is a living material that, unlike man-made ones, demonstrates continuous adaptation of its structure and mechanical properties to resist the imposed mechanical loading. Adaptation in trabecular bone is characterised by improvement of its stiffness in the loading direction and respective realignment of trabecular load-bearing architecture. Considerable experimental and simulation evidence of trabecular bone adaptation to its mechanical environment at the tissue- and organ-levels was obtained, while little attention was given to the trabecula-level of this process. This study aims to describe and classify load-driven morphological changes at the level of individual trabeculae and to propose their drivers.

Method: For this purpose, a well-established mechanoregulation-based numerical model of bone adaptation was implemented in a user-defined subroutine that changed the structural and mechanical properties of trabeculae based on the magnitude of a mechanical stimulus. This subroutine was used in conjunction with finite-element models of variously shaped structures representing trabeculae loaded in compression or shear.

Results: In all analysed cases, trabeculae underwent morphological evolution under applied compressive or shear loading. Among twelve cases analysed, six main mechanisms of morphological evolution were established: reorientation, splitting, merging, full resorption, thinning, and thickening. Moreover, all simulated cases presented the ability to reduce the mean value of von Mises stress while increasing their ability to resist compressive/shear loading during adaptation.

Conclusion: This study evaluated morphological and mechanical changes in trabeculae of different shapes in response to compressive or shear loadings and compared them based on the analysis of von Mises stress distribution as well as profiles of normal and shear stresses in the trabeculae at different stages of their adaptation.

Funding

Mega-grants program, contract no. 075-15-2021-578 of May 31, 2021, hosted by Perm National Research Polytechnic University

History

School

  • Mechanical, Electrical and Manufacturing Engineering

Published in

Computers in Biology and Medicine

Volume

168

Publisher

Elsevier

Version

  • VoR (Version of Record)

Rights holder

© The Authors

Publisher statement

This is an Open Access Article. It is published by Elsevier under the Creative Commons Attribution 4.0 International Licence (CC BY). Full details of this licence are available at: https://creativecommons.org/licenses/by/4.0/

Acceptance date

2023-11-15

Publication date

2023-11-19

Copyright date

2023

ISSN

0010-4825

eISSN

1879-0534

Language

  • en

Depositor

Prof Vadim Silberschmidt. Deposit date: 1 January 2024

Article number

107720