IJCR_Al-Qallaf_et_al.pdf (345.65 kB)

Transdermal drug delivery by microneedles: does skin metabolism matter?

Download (345.65 kB)
journal contribution
posted on 12.03.2010, 12:01 by Barrak Al-Qallaf, Daisuke Mori, Ololade Olatunji, Diganta DasDiganta Das, Zhanfeng Cui
Microneedle arrays have been shown to increase skin permeability for the transdermal delivery of drugs with high molecular weights. Various theoretical studies have been proposed to predict the drug transport behaviour after drug injection using microneedles. However it is important for the optimal design of microneedle systems to consider the effects of biological factors such as skin metabolism and variations in pharmacokinetic parameters as well as to improve the enhancement of skin permeability. A mathematical model for microneedle systems is introduced and applied to simulate the verapamil transport with metabolism in the skin. A comparative analysis for a transdermal delivery of verapamil from microneedles is presented in this paper. The results indicate that the skin metabolism does not markedly affect the skin permeation after verapamil injection using microneedles.

History

School

  • Aeronautical, Automotive, Chemical and Materials Engineering

Department

  • Chemical Engineering

Citation

AL-QALLAF, B. ... et al, 2009. Transdermal drug delivery by microneedles: does skin metabolism matter? International Journal of Chemical Reactor Engineering, 7, article A69 (pp.1-23).

Publisher

© Berkeley Electronic Press

Version

VoR (Version of Record)

Publication date

2009

Notes

This article was published in the journal, International Journal of Chemical Reactor Engineering [© Berkeley Electronic Press]: http://www.bepress.com/ijcre/vol7/A69/

ISSN

1542-6580

Language

en