Tuning colourimetric indicator displacement assays for naked-eye sensing of pyrophosphate in aqueous media
journal contribution
posted on 2015-09-15, 15:04 authored by Xuejian Liu, Huy Tien Ngo, Zijun Ge, Stephen ButlerStephen Butler, Katrina A. JolliffeA library of anion receptors comprising cyclic peptide scaffolds bearing two (ZnII-DPA) anion binding sites have been synthesised and their anion binding abilities evaluated using colourimetric indicator displacement assays with three different indicators. The resulting chemosensing ensembles provided excellent discrimination between polyphosphate ions, with several of the receptor:indicator combinations providing naked-eye sensing of pyrophosphate ions in aqueous solutions containing more than 100 fold excess of ATP.
Funding
We thank the Australian Research Council for financial support.
History
School
- Science
Department
- Chemistry
Published in
CHEMICAL SCIENCEVolume
4Issue
4Pages
1680 - 1686 (7)Citation
LIU, X. ... et al, 2013. Tuning colourimetric indicator displacement assays for naked-eye sensing of pyrophosphate in aqueous media. Chemical Science, 4 (4), pp. 1680 - 1686.Publisher
© The Royal Society of ChemistryVersion
- VoR (Version of Record)
Publisher statement
This work is made available according to the conditions of the Creative Commons Attribution 3.0 Unported (CC BY 3.0) licence. Full details of this licence are available at: http://creativecommons.org/licenses/by/3.0/Publication date
2013Notes
This is an Open Access article published by the Royal Society of Chemistry and licensed under the terms of the Creative Commons Attribution Licence, http://creativecommons.org/licenses/by/3.0/ISSN
2041-6520Publisher version
Language
- en
