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Tuning crystal morphology of succinic acid using a polymer additive

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posted on 05.03.2018, 11:23 by Anneke R. Klapwijk, Elena Simone, Zoltan NagyZoltan Nagy, Chick C. Wilson
© 2016 American Chemical Society.The effect of the triblock copolymer Pluronic P123 (PP123) on the growth of succinic acid crystals from aqueous solutions is reported at two batch process scales: 10 and 350 mL. The presence of small quantities of PP123 is shown to modify the crystal morphology from plate-like crystals to block-like crystals, in a fully reproducible manner. Increasing the quantity of polymer present, or the concentration of succinic acid used, produces needle-like crystals that are less favorable for processing. In-line process analytical tools (FBRM, PVM, and Raman) were implemented for the larger volume batch processes, allowing the crystallization to be monitored in real time. The effect of the polymer on the metastable zone width (MSZW) has also been determined in designing the crystallization experiments and is presented. In addition, the effect of the individual blocks of the copolymer, poly(ethylene glycol) and poly(propylene glycol), on the crystal morphology was examined, and these findings, together with face indexing and knowledge of the underlying crystal structure, have allowed a possible mechanism to be constructed for the interaction of the polymer with the crystal surface. This mechanism is supported by subsequent recrystallization experiments following washing of the block-like crystals with a nonpolar solvent.

Funding

This work is funded through EPSRC Grants EP/I033459/1 (CMAC Centre; C.C.W. and Z.K.N.) and EP/K503289/1 (Doctoral Training Centre in Continuous Manufacturing and Crystallization; A.R.K.). E.S. and Z.K.N. acknowledge European Research Council Grant No. [280106-CrySys] for financial support.

History

School

  • Aeronautical, Automotive, Chemical and Materials Engineering

Department

  • Chemical Engineering

Published in

Crystal Growth and Design

Volume

16

Issue

8

Pages

4349 - 4359

Citation

KLAPWIJK, A.R. ...et al., 2016. Tuning crystal morphology of succinic acid using a polymer additive. Crystal Growth and Design, 16(8), pp. 4349-4359.

Publisher

© American Chemical Society (ACS)

Version

AM (Accepted Manuscript)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/

Acceptance date

03/06/2016

Publication date

2016

Notes

This document is the Accepted Manuscript version of a Published Work that appeared in final form in Crystal Growth and Design, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.cgd.6b00465

ISSN

1528-7483

eISSN

1528-7505

Language

en

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