CG+D_FINAL-DRAFT_2020.pdf (1.78 MB)
Tuning morphology in active pharmaceutical ingredients: controlling the crystal habit of lovastatin through solvent choice and non-size-matched polymer additives
journal contributionposted on 2020-09-21, 14:19 authored by Lauren E Hatcher, Wei LiWei Li, Pollyanna Payne, Brahim BenyahiaBrahim Benyahia, Chris RiellyChris Rielly, Chick C Wilson
Additive crystallization routes to control the crystal habit of the active pharmaceutical ingredient (API) lovastatin are presented, at small scale up to 25 mL. Lovastatin is an archetypical example of an API that forms needle-like crystals via solution-based recrystallization, causing issues for downstream pharmaceutical processing stages. In this work, the size and shape of lovastatin needles are shown to be subtly influenced by the crystallization solvent, concentration, and crystallization procedure, with moderately hygroscopic ethyl acetate solvent producing needles with improved aspect ratios in comparison to the acetone/water mixtures primarily used for industrial recrystallization. Further, the inclusion of soluble, non-size-matched polymer additives, at very low concentrations (0.5 wt %/wt), into the solution has a pronounced impact on the crystal habit. While the inclusion of the hydrophilic polymer poly(ethylene glycol) promotes the formation of even longer, thinner needles than those formed by nonadditive routes, the use of hydrophobic poly(propylene glycol) improves the habit from needles toward plate-like crystals. The product materials are analyzed by a combination of microscopy, thermal analysis, and diffraction-based techniques, with the latter enabling rationalization of the habit control via identification of the prominent crystal faces and growth directions with respect to the underlying crystal structure.
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- Aeronautical, Automotive, Chemical and Materials Engineering
- Chemical Engineering
Published inCrystal Growth & Design
Pages5854 - 5862
PublisherAmerican Chemical Society (ACS)
- AM (Accepted Manuscript)
Rights holder© American Chemical Society
Publisher statementThis document is the Accepted Manuscript version of a Published Work that appeared in final form in Crystal Growth & Design, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://pubs.acs.org/doi/10.1021/acs.cgd.0c00470.