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Ultra-efficient, widely tunable gold nanoparticles-based fiducial markers for X-ray imaging

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journal contribution
posted on 25.11.2016, 11:07 by G. Maiorano, Elisa MeleElisa Mele, C. Frassanito, E. Restini, Athanassia Athanassiou, P.P. Pompa
We show the development of a new class of highly efficient, biocompatible fiducial markers for X-ray imaging and radiosurgery, based on polymer shells encapsulating engineered gold nanoparticle (AuNP) suspensions. Our smart fabrication strategy enables wide tunability of the fiducial size, shape, and X-ray attenuation performance, up to record values >20 000 Hounsfield units (HU), i.e. comparable to or even higher than bulk gold. We show that the NP fiducials allow for superior imaging both in vitro and in vivo (yet requiring 2 orders of magnitude less material), with strong stability over time and the absence of classical “streak artifacts” of standard bulk fiducials. NP fiducials were probed in vivo, showing exceptional contrast efficiency, even after 2 weeks post-implant in mice.

History

School

  • Aeronautical, Automotive, Chemical and Materials Engineering

Department

  • Materials

Published in

Nanoscale

Volume

8

Issue

45

Pages

18921 - 18927

Citation

MAIORANO, G. ...et al., 2016. Ultra-efficient, widely tunable gold nanoparticles-based fiducial markers for X-ray imaging. Nanoscale, 8, 18921.

Publisher

© Royal Society of Chemistry

Version

NA (Not Applicable or Unknown)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/

Acceptance date

07/10/2016

Publication date

2016-10-13

Notes

This paper was submitted for publication in the journal Nanoscale and the definitive published version is available at http://dx.doi.org/10.1039/C6NR07021C

ISSN

2040-3364

eISSN

2040-3372

Language

en

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