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Ultrasonically assisted cutting of bio-tissues in microtomy

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journal contribution
posted on 02.02.2017, 09:23 by Dong Wang, Anish Roy, Vadim Silberschmidt
Modern-day histology of bio-tissues for supporting stratified medicine diagnoses requires high-precision cutting to ensure high quality extremely thin specimens used in analysis. Additionally, the cutting quality is significantly affected by a wide variety of soft and hard tissues in the samples. This paper deals with development of a next generation of microtome employing introduction of controlled ultrasonic vibration to realise a hybrid cutting process of bio-tissues. The study is based on a combination of advanced experimental and numerical (finite-element) studies of multi-body dynamics of a cutting system. The quality of cut samples produced with the prototype is compared with the state-of-the-art.

Funding

The authors wish to acknowledge the Innovate UK for its funding and are very grateful to Cellpath Ltd. UK for its support.

History

School

  • Mechanical, Electrical and Manufacturing Engineering

Published in

Physics Procedia

Volume

87

Pages

118 - 124

Citation

WANG, D., ROY, A. and SILBERSCHMIDT, V.V., 2016. Ultrasonically assisted cutting of bio-tissues in microtomy. Physics Procedia, 87, pp. 118-124.

Publisher

© Elsevier

Version

VoR (Version of Record)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/

Publication date

2016-12-27

Notes

This is an Open Access article published under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0/). This conference paper was delivered at the 44th Annual Symposium of the Ultrasonic Industry Association (UIA), Washington, DC, USA, 20th-22nd April 2015.

ISSN

1875-3892

Language

en