Underlying inflammation has no impact on the oxidative stress response to acute mental stress
journal contributionposted on 01.11.2017, 11:01 by Alex Wadley, Jet J.C.S. Veldhuijzen van Zanten, Nicola Paine, Mark T. Drayson, Sarah Aldred
Introduction: Mental stress is considered to be a trigger for acute myocardial infarction (MI), with inflammation thought to provide a mechanism. Inflammation is reciprocally linked to oxidative stress, which h as also been implicated in MI. The purpose of this study was to assess the effects of experimentally-induced inflammation on the oxidative stress response to mental stress in healthy participants. Methods: Healthy males undertook one of two inflammatory stimuli: typhoid vaccination (Vaccination paradigm, N= 17) or eccentric exercise (Eccentric exercise paradigm, N= 17). All participants completed a mental arithmetic stress task twice (within-subject design): 6. h after the inflammatory stimulus, and during a control non-inflammation condition. Blood samples were taken before, immediately and 30. min after the stress task. Plasma was assessed for interleukin-6 (IL-6), protein carbonyls (PC), lipid hydroperoxides (LOOH), total antioxidant capacity (TAC) and nitric oxide metabolites (NOx). Results: Vaccination paradigm: IL-6, PC and NOx were significantly higher in the vaccination condition, relative to the control condition (p < .05). PC, TAC, LOOH and NOx were unchanged in response to mental stress in both the vaccination and control conditions. Eccentric Exercise paradigm: IL-6 and TAC were significantly higher in the eccentric exercise condition (p < .05), relative to the control condition. PC, TAC and NOx were unchanged in response to mental stress in both the eccentric exercise and control conditions. Conclusions: Two different inflammatory paradigms were successful in increasing selective plasma markers of inflammation and oxidative stress prior to a mental stress task. However, experimentally induced transient inflammation had no impact on mental stress-induced changes in plasma LOOH, PC, TAC or NOx in young healthy participants.
University of Birmingham.
- Sport, Exercise and Health Sciences