Unpicking the multiomic response to endurance training: relevance for exercise benefits in chronic kidney disease

What did the study show?

The investigators identified thousands of training-induced changes from comprehensive multitissue profiling of the transcriptome, proteome, metabolome, lipidome, post-translational modification “omes” (phosphoproteome, acetylproteome, and ubiquitylproteome), epigenome, and immunome in rats that underwent progressive treadmill endurance exercise training for 1, 2, 4, or 8 weeks, compared with sex-matched, sedentary, untrained control rats (Figure 1). [...]