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Using Super-Imposition by Translation And Rotation (SITAR) to relate pubertal growth to bone health in later life: the Medical Research Council (MRC) National Survey of Health and Development

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posted on 27.06.2016 by Tim J. Cole, Diana Kuh, Will Johnson, K.A. Ward, Laura D. Howe, Judith E. Adams, Roger Hardy, K.K. Ong
Background: To explore associations between pubertal growth and later bone health in a cohort with infrequent measurements, using another cohort with more frequent measurements to support the modelling, data from the MRC National Survey of Health and Development (2-26 years, 4901/30 004 subjects/measurements) and the Avon Longitudinal Study of Parents and Children (5-20 years) (10 896/74 120) were related to NSHD bone health outcomes at 60-64 years. Methods: NSHD data were analysed using SITAR growth curve analysis, either alone or jointly with ALSPAC data. Improved estimation of pubertal growth parameters of size, tempo and velocity was assessed by changes in model fit and correlations with contemporary measures of pubertal timing. Bone outcomes of radius (trabecular volumetric bone mineral density (vBMD) and diaphysis cross-sectional area (CSA)) were regressed on the SITAR parameters, adjusted for current body size. Results: The NSHD SITAR parameters were better estimated in conjunction with ALSPAC, i.e. more strongly correlated with pubertal timing. Trabecular vBMD was associated with early height tempo, while diaphysis CSA was related to weight size, early tempo and slow velocity, the bone outcomes being around 15% higher for the better versus worse growth pattern. Conclusions: By pooling NSHD and ALSPAC data, SITAR more accurately summarised pubertal growth and weight gain in NSHD, and in turn demonstrated notable associations between pubertal timing and later bone outcomes. These associations give insight into the importance of the pubertal period for future skeletal health and osteoporosis risk.

Funding

The research was supported by the National Institute for Health Research Biomedical Research Centre at Great Ormond Street Hospital for Children NHS Foundation Trust and University College London.

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  • Sport, Exercise and Health Sciences

Published in

International Journal of Epidemiology

Citation

COLE, T.J. ... et al, 2016. Using Super-Imposition by Translation And Rotation (SITAR) to relate pubertal growth to bone health in later life: the Medical Research Council (MRC) National Survey of Health and Development. International Journal of Epidemiology, 45(4), pp.1125-1134.

Publisher

© Oxford University Press

Version

AM (Accepted Manuscript)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/

Acceptance date

09/05/2016

Publication date

2016-07-27

Notes

This is a pre-copyedited, author-produced version of an article accepted for publication in International Journal of Epidemiology following peer review. The version of record COLE, T.J. ... et al, 2016. Using Super-Imposition by Translation And Rotation (SITAR) to relate pubertal growth to bone health in later life: the Medical Research Council (MRC) National Survey of Health and Development. International Journal of Epidemiology, 45(4), pp.1125-1134 is available online at: http://dx.doi.org/10.1093/ije/dyw134.

ISSN

1464-3685

Language

en

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