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Wet milling, seeding, and ultrasound in the optimization of the oiling-out crystallization process

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posted on 2022-01-17, 15:25 authored by Liping Wang, Huaiyu YangHuaiyu Yang, Zhuang Sun, Ying Bao, Qiuxiang Yin
Complicated solution environments in oiling-out crystallization can lead to particle agglomeration with large size distribution and low purity of the products, due to complex interactions among two liquid phases and one solid phase during the oiling out crystallization. This research mainly focuses on optimization of size distribution by control particle agglomeration during the oiling-out crystallization process in model system of propyl paraben-ethanol-water. Nucleation-control technologies, wet milling, seeding and ultrasound were investigated to limit the agglomeration. Further investigations of wet milling was applied before the nucleation or in the crystal growth process with different geometries, such as the coarse, medium and fine rotor-stator tooth pairs. An integrated process analytical technology tools (PAT) array, including focused beam reflectance measurement (FBRM), particle visual monitoring(PVM), 2 and attenuated total reflectance ultraviolet/visible(ATR-UV/vis), was used to observe the droplet formation of the dispersed phase, size distributions, particle shapes during the nucleation and crystal growth. The results demonstrate that wet milling, seeding and ultrasound technologies can help to the control of the particle size distribution in the complex solution environments with different levels of efficiencies

Funding

China Scholarship Council, National Natural Foundation of China (nos. 21576187 and 21776203)

Tianjin Municipal Natural Science Foundation (no. 18JCYBJC21100)

Regenerative BioCrystallisation

Engineering and Physical Sciences Research Council

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Royal Society (IEC\NSFC\201432)

History

School

  • Aeronautical, Automotive, Chemical and Materials Engineering

Department

  • Chemical Engineering

Published in

Industrial & Engineering Chemistry Research

Volume

60

Issue

50

Pages

18452 - 18463

Publisher

American Chemical Society (ACS)

Version

  • AM (Accepted Manuscript)

Rights holder

© American Chemical Society

Publisher statement

This paper was accepted for publication in the journal Industrial & Engineering Chemistry Research and the definitive published version is available at https://doi.org/10.1021/acs.iecr.1c04167

Acceptance date

2021-12-03

Publication date

2021-12-13

Copyright date

2021

ISSN

0888-5885

eISSN

1520-5045

Language

  • en

Depositor

Dr Huaiyu Yang. Deposit date: 14 January 2022

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