Development of novel drug formulation using microfluidic device
posterposted on 18.07.2012, 15:16 by Ekanem E. Ekanem, Yuk Yeung Shiu, Zhandos Tauanov, Lav Sharma, Hamed Shahmohamadi, John V. Henry, Diganta Bhusan Das, Goran Vladisavljevic
Poster introduction: Biosorbable poly(lactic acid) (PLA) microspheres have been used for controlled drug release, as ultrasound contrast agents, for cell cultivation in tissue engineering, fabrication of scaffolds, composite coatings, etc. Coherent PLA particles can be fabricated via single emulsion route. First, PLA is dissolved in a volatile organic solvent (DCM) and this solution is emulsified in an aqueous surfactant solution. In the next stage, the resultant droplets are solidified by evaporation of solvent. Porous PLA particles can be produced via W/O/W emulsion route, where first, an inner water phase is dispersed in a mixture of PLA and DCM in the presence of oil-soluble surfactant form a W/O emulsion. This emulsion is then dispersed drop-wise into an aqueous surfactant solution to form a W/O/W emulsion. W/O particles are formed by evaporation of DCM.
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