Development of Novel Drug Formulation Using Microfluidic Device.pdf (389.46 kB)

Development of novel drug formulation using microfluidic device

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poster
posted on 18.07.2012, 15:16 by Ekanem E. Ekanem, Yuk Yeung Shiu, Zhandos Tauanov, Lav Sharma, Hamed Shahmohamadi, John V. Henry, Diganta Bhusan Das, Goran Vladisavljevic
Poster introduction: Biosorbable poly(lactic acid) (PLA) microspheres have been used for controlled drug release, as ultrasound contrast agents, for cell cultivation in tissue engineering, fabrication of scaffolds, composite coatings, etc. Coherent PLA particles can be fabricated via single emulsion route. First, PLA is dissolved in a volatile organic solvent (DCM) and this solution is emulsified in an aqueous surfactant solution. In the next stage, the resultant droplets are solidified by evaporation of solvent. Porous PLA particles can be produced via W/O/W emulsion route, where first, an inner water phase is dispersed in a mixture of PLA and DCM in the presence of oil-soluble surfactant form a W/O emulsion. This emulsion is then dispersed drop-wise into an aqueous surfactant solution to form a W/O/W emulsion. W/O particles are formed by evaporation of DCM.

History

School

  • Aeronautical, Automotive, Chemical and Materials Engineering

Department

  • Chemical Engineering

Citation

EKANEM, E.E. ... et al, 2012. Development of novel drug formulation using microfluidic device. 11th UK Particle Technology Forum 2012 "Formulating with particles", Loughborough University, 4th-5th April.

Publication date

2012

Notes

This is a conference poster.

Language

en

Exports

Loughborough Publications

Keywords

Exports